SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation

S Li, Y Zhang, Z Guan, H Li, M Ye, X Chen… - Signal transduction and …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to
respiratory illness and multi-organ failure in critically ill patients. Although the virus-induced …

Emerging insights on caspases in COVID-19 pathogenesis, sequelae, and directed therapies

TA Premeaux, ST Yeung, Z Bukhari, S Bowler… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), remains a significant global health emergency with new …

COVID-19 coagulopathy and antiphospholipid syndrome

M Serrano, G Espinosa, R Cervera… - Revista Colombiana de …, 2022 - Elsevier
The presence of thrombotic events in COVID-19 patients has been described since the
beginning of the pandemic. This association has been confirmed in most of the reported …

[HTML][HTML] Quercetin, a natural flavonoid, protects against hepatic ischemia–reperfusion injury via inhibiting Caspase-8/ASC dependent macrophage pyroptosis

J Lin, F Li, J Jiao, Y Qian, M Xu, F Wang, X Sun… - Journal of Advanced …, 2024 - Elsevier
Introduction Hepatic ischemia–reperfusion injury (IRI) is an inevitable adverse event
following liver surgery, leading to liver damage and potential organ failure. Despite …

[HTML][HTML] Human gastric fibroblasts ameliorate A20-dependent cell survival in co-cultured gastric epithelial cells infected by Helicobacter pylori

P Jantaree, Y Yu, S Chaithongyot, C Täger… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Crosstalk within the gastric epithelium, which is closely in contact with stromal fibroblasts in
the gastric mucosa, has a pivotal impact in proliferation, differentiation and transformation of …

[HTML][HTML] PARP inhibitors enhance antitumor immune responses by triggering pyroptosis via TNF–caspase 8–GSDMD/E axis in ovarian cancer

Y Xia, P Huang, Y Qian, Z Wang, N Jin… - Journal for …, 2024 - pmc.ncbi.nlm.nih.gov
Background In addition to their established action of synthetic lethality in tumor cells, poly
(ADP-ribose) polymerase inhibitors (PARPis) also orchestrate tumor immune …

Pulmonary inflammatory response in lethal COVID-19 reveals potential therapeutic targets and drugs in phases III/IV clinical trials

A López-Cortés, S Guerrero, E Ortiz-Prado… - Frontiers in …, 2022 - frontiersin.org
Background: It is imperative to identify drugs that allow treating symptoms of severe COVID-
19. Respiratory failure is the main cause of death in severe COVID-19 patients, and the host …

[HTML][HTML] Polymorphisms Influence the Expression of the Fas and FasL Genes in COVID-19

WR dos Santos Brito, WB de Brito… - International Journal of …, 2025 - mdpi.com
The apoptotic molecule Fas and its ligand FasL are involved in the process of T-lymphocyte
death, which may lead to lymphopenia, a characteristic of severe coronavirus disease 2019 …

[HTML][HTML] Molecular docking and in silico analysis of the pharmacokinetics, toxicological profile and differential gene expression of bioactive compounds from …

NGR Araujo, FC da Silva Junior, LV de Souza Santos… - Toxicology Reports, 2024 - Elsevier
The genus Cyrtopodium, from the Orchidaceae family, is widely used for its therapeutic
properties in the treatment of tuberculosis, abscesses, urinary infection, and colds. C …

FADD cooperates with Caspase-8 to positively regulate the innate immune response and promote apoptosis following bacterial infection in Japanese eel

T Wang, P Lin, Y Wang, Y Chen, Z Zhang, F Li… - Fish & Shellfish …, 2025 - Elsevier
Fas-associated protein with Death Domain (FADD) is a crucial signaling component of
apoptosis and a vital immunomodulator on inflammatory signaling pathways. However …