Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …

Breast cancer stands as the most prevalent cancer in women globally, and contributes to the
highest percentage of mortality due to cancer-related deaths in women. Paclitaxel (PTX) is …

Perfectly orchestrated periodic gene expression during cell cycle progression is essential for
maintaining genome integrity and ensuring that cell proliferation can be stopped by …

Valerian root (Valeriana officinalis) is a popular and widely available herbal supplement
used to treat sleeping disorders and insomnia. The herb's ability to ameliorate sleep …

Histone modifications (HMs) contribute to maintaining genomic stability, transcription, DNA
repair, and modulating chromatin in cancer cells. Furthermore, HMs are dynamic and …

Inhibitors of bromodomain and extra-terminal proteins (BETi) suppress oncogenic gene
expression and have been shown to be efficacious in many in vitro and murine models of …

Bromodomain and extraterminal domain (BET) proteins are epigenetic molecules that
regulate the expression of multiple genes involved in carcinogenesis. Breast cancer is an …

Super-enhancers (SEs) refer to large clusters of enhancers that drive gene expressions.
Recent data has provided novel insights in elucidating the roles of SEs in many diseases …

Breast cancer is a collection of distinct tumor subtypes that are driven by unique gene
expression profiles. These transcriptomes are controlled by various epigenetic marks that …

Background Bromodomain and extraterminal proteins (BETs) are more than just epigenetic
regulators of transcription. Here we highlight a new role for the BET protein BRD4 in the …