Neuroinflammation in Huntington's disease: From animal models to clinical therapeutics

Q Jia, S Li, XJ Li, P Yin - Frontiers in Immunology, 2022 - frontiersin.org
Huntington's disease (HD) is a progressive neurodegenerative disease characterized by
preferential loss of neurons in the striatum in patients, which leads to motor and cognitive …

Oligodendrocytes and myelin: Active players in neurodegenerative brains?

JF Chen, F Wang, NX Huang, L Xiao… - Developmental …, 2022 - Wiley Online Library
Oligodendrocytes (OLs) are a major type of glial cells in the central nervous system that
generate multiple myelin sheaths to wrap axons. Myelin ensures fast and efficient …

Insights into white matter defect in Huntington's disease

Y Sun, H Tong, T Yang, L Liu, XJ Li, S Li - Cells, 2022 - mdpi.com
Huntington's disease (HD) is an autosomal-dominant inherited progressive
neurodegenerative disorder. It is caused by a CAG repeat expansion in the Huntingtin gene …

Enhanced meningeal lymphatic drainage ameliorates lipopolysaccharide-induced brain injury in aged mice

H Dong, X Dai, Y Zhou, C Shi, P Bhuiyan, Z Sun… - Journal of …, 2024 - Springer
Background Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction
caused by sepsis. Neuroinflammation induced by sepsis is considered a potential …

Early white matter pathology in the fornix of the limbic system in Huntington disease

S Gabery, JE Kwa, RY Cheong, B Baldo… - Acta …, 2021 - Springer
Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded
CAG repeat in the huntingtin (HTT) gene. The typical motor symptoms have been associated …

Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington's disease reveals early gray and white matter alterations

JB Pérot, M Célestine, M Palombo… - Human molecular …, 2022 - academic.oup.com
Pathogenesis of the inherited neurodegenerative disorder Huntington's disease (HD) is
progressive with a long presymptomatic phase in which subtle changes occur up to 15 years …

Mutant HTT does not affect glial development but impairs myelination in the early disease stage

S Yang, J Ma, H Zhang, L Chen, Y Li, M Pan… - Frontiers in …, 2023 - frontiersin.org
Introduction Huntington's disease (HD) is caused by expanded CAG repeats in the
huntingtin gene (HTT) and is characterized by late-onset neurodegeneration that primarily …

Spatial proteomic alterations detected via MALDI-MS imaging implicate neuronal loss in a Huntington's disease mouse (YAC128) brain

M Karayel-Basar, I Uras, I Kiris, B Sahin, E Akgun… - Molecular omics, 2022 - pubs.rsc.org
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that
occurs with the increase of CAG trinucleotide repeats in the huntingtin gene. To understand …

Identification of candidate biomarkers and pathways associated with multiple sclerosis using bioinformatics and next generation sequencing data analysis

B Vastrad, C Vastrad - bioRxiv, 2023 - biorxiv.org
Multiple sclerosis (MS) is the main reason for disability caused by autoimmunity. However,
effective biomarkers for MS have not been identified. This study explored the molecular …

Magnoflorine alleviates dextran sulfate sodium‐induced ulcerative colitis via inhibiting JAK2/STAT3 signaling pathway

J Wen, Y Yang, L Li, J Xie, J Yang… - Phytotherapy …, 2024 - Wiley Online Library
Magnoflorine (Mag), a natural alkaloid component originating from the Ranunculaceae Juss.
Family, has a various of pharmacological activities. This study aimed to investigate the …