Novel molecular hybrids of EGCG and quinoxaline: Potent multi-targeting antidiabetic agents that inhibit α-glucosidase, α-amylase, and oxidative stress
M Kothari, K Kannan, R Sahadevan… - International Journal of …, 2024 - Elsevier
Diabetes mellitus is a multifactorial disease and its effective therapy often demands several
drugs with different modes of action. Herein, we report a rational design and synthesis of …
drugs with different modes of action. Herein, we report a rational design and synthesis of …
Protein S-palmitoylation is markedly inhibited by 4 ″-alkyl ether lipophilic derivatives of EGCG, the major green tea polyphenol: In vitro and in silico studies
S-palmitoylation is a dynamic lipid-based protein post-translational modification facilitated
by a family of protein acyltransferases (PATs) commonly known as DHHC-PATs or DHHCs …
by a family of protein acyltransferases (PATs) commonly known as DHHC-PATs or DHHCs …
Lipophilic derivatives of EGCG as potent α-amylase and α-glucosidase inhibitors ameliorating oxidative stress and inflammation
Uncontrolled hyperglycemia leads to increased oxidative stress, chronic inflammation, and
insulin resistance, rendering diabetes management harder to accomplish. To tackle these …
insulin resistance, rendering diabetes management harder to accomplish. To tackle these …