The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth
and tumorigenesis is emerging beyond Warburg as an area of research that is under …

Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by the
progressive loss of cholinergic neurons, leading to the onset of severe behavioral, motor …

1112 ELROD JW et al. red-sensitive mechanism (now known to be the mitochondrial
calcium uniporter (MCU), the genetic identity of which was recently discovered14–16) and …

Hexokinase isoforms I and II bind to mitochondrial outer membranes in large part by
interacting with the outer membrane voltage-dependent anion channel (VDAC). This …

Although functional coupling between protein kinase Cε (PKCε) and mitochondria has been
implicated in the genesis of cardioprotection, the signal transduction mechanisms that …

Cancer and neurodegeneration are different classes of diseases that share the involvement
of mitochondria in their pathogenesis. Whereas the high glycolytic rate (the so-called …

Regulation of mitochondrial physiology requires an efficient exchange of molecules
between mitochondria and the cytoplasm via the outer mitochondrial membrane (OMM). The …

The heart is a dynamic organ capable of significant architectural remodeling, cellular
adaptations, and molecular reprogramming following both physiologic and pathologic …