The founding member of the lipoprotein receptor family, low-density lipoprotein receptor
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …

Over the last 50 years, the reeler mutant mouse has become an important model for studying
normal and abnormal development in the cerebral cortex and other regions of the brain …

Normal development of the cerebral cortex requires long-range migration of cortical neurons
from proliferative regions deep in the brain. Lissencephaly (“smooth brain,” from “lissos,” …

Reelin is a glycoprotein that serves important roles both during development (regulation of
neuronal migration and brain lamination) and in adulthood (maintenance of synaptic …

▪ Abstract The low-density–lipoprotein (LDL) receptor family is an evolutionarily ancient
gene family of structurally closely related cell-surface receptors. Members of the family are …

Accumulation of neurobiological knowledge points to neurodevelopmental origins for certain
psychotic and mood disorders. Recent landmark postmortem reports implicate Reelin, a …

BACKGROUND: Autism is a severe neurodevelopmental disorder with genetic and
environmental etiologies. Recent genetic linkage studies implicate Reelin glycoprotein in …

Reelin was originally identified as a regulator of neuronal migration and synaptic function,
but its non-neuronal functions have received far less attention. Reelin participates in organ …

Dentate granule cell (DGC) neurogenesis persists throughout life in the mammalian
hippocampal dentate gyrus and increases after epileptogenic insults. The DGC layer in …

Reelin is a glycoprotein that is essential for the correct cytoarchitectonic organization of the
developing CNS. Its function in the adult brain is less understood, although it has been …