Molecular motors are machines essential for life since they convert chemical energy into
mechanical work. However, the precise mechanism by which nucleotide binding, catalysis …

Chemical agents are classified into chaotropes (disorder inducing) and kosmotropes (order
inducing) based on their ability to destabilize or stabilize, respectively, the structure of …

Immunoglobulin heavy-chain-binding protein (BiP protein) is a 75-kDa Hsp70 monomeric
ATPase motor that plays broad and crucial roles maintaining proteostasis inside the cell. Its …

Abstract Immunoglobulin Binding Protein (BiP) is a chaperone and molecular motor
belonging to the Hsp70 family, involved in the regulation of important biological processes …

The abundance of available static protein structural data makes the more effective analysis
and interpretation of this data a valuable tool to supplement the experimental study of …

Molecular Machines presents a dynamic new approach to the physics of enzymes and DNA
from the perspective of materials science. Unified around the concept of molecular …

Pursuing a materials science approach to understanding the deformability of enzymes, we
introduce measurements of the phase of the mechanical response function within the …

Biological macromolecules such as proteins are remarkable machines at the nano scale.
The mechanical motion of proteins that is present in every living system allows those …

This thesis studied the Guanylate Kinase (GK) enzyme, which catalyzes the reaction of ATP
into ADP, using nano-rheological techniques. A unique experimental setup was created in …