Paediatric and adult glioblastoma: multiform (epi) genomic culprits emerge
We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
[HTML][HTML] Newly diagnosed glioblastoma: a review on clinical management
Glioblastoma is an aggressive primary tumor of the central nervous system. This review will
focus on clinical developments and management of newly diagnosed disease, including a …
focus on clinical developments and management of newly diagnosed disease, including a …
Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumor in humans. Here we show that gliomas can originate from differentiated cells in the …
tumor in humans. Here we show that gliomas can originate from differentiated cells in the …
Single-cell transcriptomics uncovers glial progenitor diversity and cell fate determinants during development and gliomagenesis
The identity and degree of heterogeneity of glial progenitors and their contributions to brain
tumor malignancy remain elusive. By applying lineage-targeted single-cell transcriptomics …
tumor malignancy remain elusive. By applying lineage-targeted single-cell transcriptomics …
Single-cell transcriptome analysis of lineage diversity in high-grade glioma
J Yuan, HM Levitin, V Frattini, EC Bush, DM Boyett… - Genome medicine, 2018 - Springer
Background Despite extensive molecular characterization, we lack a comprehensive
understanding of lineage identity, differentiation, and proliferation in high-grade gliomas …
understanding of lineage identity, differentiation, and proliferation in high-grade gliomas …
MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma
BJ Gill, DJ Pisapia, HR Malone… - Proceedings of the …, 2014 - National Acad Sciences
Glioblastomas (GBMs) diffusely infiltrate the brain, making complete removal by surgical
resection impossible. The mixture of neoplastic and nonneoplastic cells that remain after …
resection impossible. The mixture of neoplastic and nonneoplastic cells that remain after …
The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma
KPL Bhat, KL Salazar… - Genes & …, 2011 - genesdev.cshlp.org
Recent molecular classification of glioblastoma (GBM) has shown that patients with a
mesenchymal (MES) gene expression signature exhibit poor overall survival and treatment …
mesenchymal (MES) gene expression signature exhibit poor overall survival and treatment …
A secreted PTEN phosphatase that enters cells to alter signaling and survival
BD Hopkins, B Fine, N Steinbach, M Dendy, Z Rapp… - Science, 2013 - science.org
Phosphatase and tensin homolog on chromosome ten (PTEN) is a tumor suppressor and an
antagonist of the phosphoinositide-3 kinase (PI3K) pathway. We identified a 576–amino …
antagonist of the phosphoinositide-3 kinase (PI3K) pathway. We identified a 576–amino …
Cell of origin for malignant gliomas and its implication in therapeutic development
Malignant glioma remains incurable despite tremendous advancement in basic research
and clinical practice. The identification of the cell (s) of origin should provide deep insights …
and clinical practice. The identification of the cell (s) of origin should provide deep insights …
The neurobiology of gliomas: from cell biology to the development of therapeutic approaches
M Westphal, K Lamszus - Nature Reviews Neuroscience, 2011 - nature.com
Gliomas are the most common type of primary brain tumour and are often fast growing with a
poor prognosis for the patient. Their complex cellular composition, diffuse invasiveness and …
poor prognosis for the patient. Their complex cellular composition, diffuse invasiveness and …