[HTML][HTML] Antigenic evolution of SARS coronavirus 2

AZ Mykytyn, RAM Fouchier, BL Haagmans - Current Opinion in Virology, 2023 - Elsevier
SARS coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, emerged in China in
December 2019. Vaccines developed were very effective initially, however, the virus has …

Omicron BA. 1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes

J Quandt, A Muik, N Salisch, BG Lui, S Lutz… - Science …, 2022 - science.org
Omicron is the evolutionarily most distinct severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variant of concern (VOC) to date. We report that Omicron BA. 1 breakthrough …

[HTML][HTML] Molecular basis of receptor binding and antibody neutralization of Omicron

Q Hong, W Han, J Li, S Xu, Y Wang, C Xu, Z Li, Y Wang… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant exhibits striking immune evasion and is
spreading rapidly worldwide. Understanding the structural basis of the high transmissibility …

[HTML][HTML] Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike

AG Wrobel - Current Opinion in Structural Biology, 2023 - Elsevier
Spike glycoprotein of SARS-CoV-2 mediates viral entry into host cells by facilitating virus
attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its …

Omicron BA. 2 breakthrough infection enhances cross-neutralization of BA. 2.12. 1 and BA. 4/BA. 5

A Muik, BG Lui, M Bacher, AK Wallisch, A Toker… - Science …, 2022 - science.org
BNT162b2-vaccinated individuals after Omicron BA. 1 breakthrough infection have strong
serum-neutralizing activity against Omicron BA. 1, BA. 2, and previous SARS-CoV-2 variants …

Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein

V Calvaresi, AG Wrobel, J Toporowska… - Nature …, 2023 - nature.com
SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequent membrane
fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 …

Key mutations in the spike protein of SARS‐CoV‐2 affecting neutralization resistance and viral internalization

Q Wang, SB Ye, ZJ Zhou, AL Song… - Journal of Medical …, 2023 - Wiley Online Library
To control the ongoing COVID‐19 pandemic, a variety of severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) vaccines have been developed. However, the rapid mutations …

In situ architecture and membrane fusion of SARS-CoV-2 Delta variant

Y Song, H Yao, N Wu, J Xu, Z Zhang… - Proceedings of the …, 2023 - National Acad Sciences
Among the current five Variants of Concern, infections caused by SARS-CoV-2 B. 1.617. 2
(Delta) variant are often associated with the greatest severity. Despite recent advances on …

Structure, anti-SARS-CoV-2, and anticoagulant effects of two sulfated galactans from the red alga Botryocladia occidentalis

AK Maurya, P Sharma, P Samanta, AA Shami… - International Journal of …, 2023 - Elsevier
The structure of the sulfated galactan from the red alga Botryocladia occidentalis (BoSG)
was originally proposed as a simple repeating disaccharide of alternating 4-linked α …

Borneol ester derivatives as entry inhibitors of a wide spectrum of SARS-CoV-2 viruses

OI Yarovaya, DN Shcherbakov, SS Borisevich… - Viruses, 2022 - mdpi.com
In the present work we studied the antiviral activity of the home library of monoterpenoid
derivatives using the pseudoviral systems of our development, which have glycoproteins of …