Over the past 20 years, there has been considerable progress in our understanding of the
biological functions of the BRCA1 and BRCA2 cancer susceptibility genes. This has led to …

DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity.
Failure to repair a DSB has deleterious consequences, including genomic instability and cell …

Germline mutations in BRCA1/2 predispose individuals to breast cancer (termed germline-
mutated BRCA1/2 breast cancer, gBRCA-BC) by impairing homologous recombination (HR) …

Triple-negative breast cancer (TNBC) accounts for 15% of all breast cancers and is
associated with poor long-term outcomes compared with other breast cancer subtypes …

Chemotherapy is the primary established systemic treatment for patients with triple-negative
breast cancer (TNBC) in both the early and advanced-stages of the disease. The lack of …

Activation of a telomere maintenance mechanism (TMM) is permissive for replicative
immortality and a hallmark of human cancer. While most cancers rely on reactivation of …

Global loss of DNA methylation is frequently observed in the genome of human tumors.
Although this epigenetic alteration is clearly associated with cancer progression, the way it …

Tumour-specific antigens have been an area of interest in cancer therapy since their
discovery in the middle of the 20th century. In the era of immune-based cancer therapeutics …

The molecular heterogeneity and distinct features of HER2-low breast cancers, particularly
in the Chinese population, are not well understood, limiting its precise management in the …

DNA damage tolerance and mutagenesis are hallmarks and enabling characteristics of
neoplastic cells that drive tumorigenesis and allow cancer cells to resist therapy. The 'Y …