[HTML][HTML] Netarsudil increases outflow facility in human eyes through multiple mechanisms

R Ren, G Li, TD Le, C Kopczynski… - … & visual science, 2016 - jov.arvojournals.org
Purpose: Netarsudil is a Rho kinase/norepinephrine transporter inhibitor currently in phase
3 clinical development for glaucoma treatment. We investigated the effects of its active …

An enhanced deep image model for glaucoma diagnosis using feature-based detection in retinal fundus

LK Singh, Pooja, H Garg, M Khanna… - Medical & Biological …, 2021 - Springer
This paper proposes a deep image analysis–based model for glaucoma diagnosis that uses
several features to detect the formation of glaucoma in retinal fundus. These features are …

Performance evaluation of various deep learning based models for effective glaucoma evaluation using optical coherence tomography images

LK Singh, Pooja, H Garg, M Khanna - Multimedia Tools and Applications, 2022 - Springer
Glaucoma is the dominant reason for irreversible blindness worldwide, and its best remedy
is early and timely detection. Optical coherence tomography has come to be the most …

A small molecule inhibitor of VE-PTP activates Tie2 in Schlemm's canal increasing outflow facility and reducing intraocular pressure

G Li, AF Nottebaum, M Brigell… - … & visual science, 2020 - iovs.arvojournals.org
Purpose: Tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2)
activation in Schlemm's canal (SC) endothelium is required for the maintenance of IOP …

Rho-kinase inhibitors offer a new approach in the treatment of glaucoma

P Challa, JJ Arnold - Expert opinion on investigational drugs, 2014 - Taylor & Francis
Introduction: Primary open-angle glaucoma (POAG) is a leading cause for worldwide
blindness and is characterized by progressive optic nerve damage. The etiology of POAG is …

An IoT based predictive modeling for Glaucoma detection in optical coherence tomography images using hybrid genetic algorithm.

LK Singh, H Garg, M Khanna - Multimedia Tools & …, 2022 - search.ebscohost.com
The primary cause of irreversible blindness due to glaucoma is a silent, progressive disease
with no noticeable symptoms. This eye disease gradually and rapidly damages the optic …

Effect of low-fat dietary modification on incident open-angle glaucoma

R Mehta, RM Ray, LM Tussing-Humphreys… - Ophthalmology, 2023 - Elsevier
Purpose We tested whether dietary modification (DM) altered the risk for incident primary
open-angle glaucoma (POAG). Design Secondary analysis of a randomized intervention …

A novel hybrid robust architecture for automatic screening of glaucoma using fundus photos, built on feature selection and machine learning‐nature driven computing

LK Singh, M Khanna, S Thawkar - Expert Systems, 2022 - Wiley Online Library
Glaucoma is a leading cause of permanent vision loss. Early detection and treatment of this
infection is critical for recovery and slowing the progression of vision loss. An efficient novel …

Effects of hormone therapy on intraocular pressure: the Women's Health Initiative-Sight Exam Study

TS Vajaranant, PM Maki, LR Pasquale, A Lee… - American journal of …, 2016 - Elsevier
Purpose Previous studies suggest that hormone therapy favorably affects intraocular
pressure (IOP). Here, we examined the association between hormone therapy use and IOP …

[HTML][HTML] PGC-1α signaling coordinates susceptibility to metabolic and oxidative injury in the inner retina

X Guo, ES Dason, V Zanon-Moreno, Q Jiang… - The American journal of …, 2014 - Elsevier
Retinal ganglion cells (RGCs), used as a common model of central nervous system injury,
are particularly vulnerable to metabolic and oxidative damage. However, molecular …