Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …

How environmental nutrient availability impacts T cell metabolism and function remains
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) …

Mammalian organs convert dietary nutrients into circulating metabolites and share them to
maintain whole-body metabolic homeostasis. While the concentrations of circulating …

Blood metabolome is commonly used in human studies to explore the associations of gut
microbiota-derived metabolites with cardiometabolic diseases. Here, in a cohort of 1007 …

Over a billion people across the world experience a high rate of missed disease diagnosis,
an issue that highlights the need for diagnostic tools showing increased accuracy and …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause
cystic fibrosis (CF), a multiorgan disease that is characterized by diverse metabolic defects …

Heart failure (HF) is a leading cause of mortality. Failing hearts undergo profound metabolic
changes, but a comprehensive evaluation in humans is lacking. We integrate plasma and …

Glutamine is a conditionally essential nutrient for many cancer cells, but it remains unclear
how consuming glutamine in excess of growth requirements confers greater fitness to …

Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated
that enhanced BAT thermogenesis is tightly associated with increased energy expenditure …

Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD+) levels are
hallmarks of skeletal muscle ageing and sarcopenia,–, but it is unclear whether these …