Highlights•IL-17 and its receptors have a key role in regulation of neuroinflammation during
chronic neurodegenerative diseases.•Clinical studies in patients with neurodegenerative …

Background Individuals who have experienced mild traumatic brain injuries (mTBIs) suffer
from several comorbidities, including chronic pain. Despite extensive studies investigating …

Complete Freund's adjuvant (CFA) is used as a standard adjuvant for the induction of
experimental autoimmune encephalomyelitis (EAE), the most commonly used animal model …

Opioid use disorder (OUD) is an ongoing public health concern in the United States, and
relatively little work has addressed how genetic background contributes to OUD …

Ion channels play an important role in mediating pain through signal transduction,
regulation, and control of responses, particularly in neuropathic pain. Transient receptor …

Multiple sclerosis (MS) is a neurodegenerative and autoimmune disease affecting the
central nervous system (CNS). The precise etiology of MS is still undeciphered, and signs …

Dietary fibres are typically fermented by gut microbes, producing beneficial short-chain fatty
acids (SCFAs). In chronic diseases like inflammatory bowel disease (IBD), studies show …

In traumatic spinal cord injury (SCI), a primary mechanical insult to the spinal cord causes
immediate tissue damage and neurological dysfunction. The primary injury is followed by a …