Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event leading
to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD) …

Sepsis is the leading cause of death in critically ill patients in the United States. Yet the
individual host response to septicemia is variable, depending on the patient's immune …

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
industrialized nations, affecting 30–50 million people worldwide. The earliest clinical …

Sepsis, a medical emergency, is the overwhelming host response to infection leading to
organ failure. The pathophysiology of this heterogeneous disease includes an inflammatory …

IL-6 is known to be an important pro-and anti-inflammatory cytokine, which is up-regulated
during sepsis. Our previous work has suggested a role for IL-6 in the up-regulation of C5aR …

Sepsis pathogenesis is complex and heterogeneous; hence, a precision-medicine strategy
is needed. Acute kidney injury (AKI) following sepsis portends higher mortality …

Sepsis represents a major cause of death in intensive care units. Here we show that
administration of lysophosphatidylcholine (LPC), an endogenous lysophospholipid …

A major function of the immune system is to protect the host from microbial infections. The
complement system plays important roles in both the innate and the adaptive immune …

C5a anaphylatoxin, a potent inflammatory mediator, is known to act through a specific G
protein coupled receptor. However, some of the complex effects of C5a in vivo may not be …