Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural
hearing loss, after age-related hearing loss, and affects approximately 5% of the world's …

Background Noise-induced hearing loss is one of the most common forms of sensorineural
hearing loss, is a major health problem, is largely preventable and is probably more …

Epidemiological studies have provided evidence that traffic noise exposure is linked to
cardiovascular diseases such as arterial hypertension, myocardial infarction, and stroke …

Caloric restriction (CR) extends the life span and health span of a variety of species and
slows the progression of age-related hearing loss (AHL), a common age-related disorder …

Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …

The early observations on the rate-of-living theory by Max Rubner and the report by
Gershman that oxygen free radicals exist in vivo culminated in the seminal proposal in the …

Sensorineural hearing loss (SNHL) can either be genetically inherited or acquired as a
result of aging, noise exposure, or ototoxic drugs. Although the precise pathophysiological …

To assess the dynamics of noise-induced tissue injury and repair, groups of CBA/CaJ mice
were exposed to an octave-band noise for 2 hours at levels of 94, 100, 106, 112, or 116 dB …

We describe a novel phenotype in mice lacking the major antioxidant enzyme, CuZn-
superoxide dismutase (Sod1−/− mice), namely a dramatic acceleration of age-related loss of …

Gain-of-function mutations in the Cu, Zn-superoxide dismutase (SOD1) gene are implicated
in progressive motor neuron death and paralysis in one form of inherited amyotrophic lateral …