Monomethylation of lysine 20 of histone H4 (H4K20me1) is catalyzed by Set8 and thought to
play important roles in many aspects of genome function that are mediated by H4K20me …

Methylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is
interpreted by epigenetic readers that assist transcription and safeguard the integrity of the …

Aging is a multifactorial process that disturbs homeostasis, increases disease susceptibility,
and ultimately results in death. Although the definitive set of molecular mechanisms …

Mutating replication-dependent (RD) histone genes is an important tool for understanding
chromatin-based epigenetic regulation. Deploying this tool in metazoans is particularly …

Histone variants are the paralogs of core histones (H2A, H2B, H3 and H4). They are stably
expressed throughout the cell cycle in a replication-independent fashion and are capable of …

Transposable elements constitute a substantial portion of most eukaryotic genomes and
their activity can lead to developmental and neuronal defects. In the germline, transposon …

The chromatin of animal cells contains two types of histones: canonical histones that are
expressed during S phase of the cell cycle to package the newly replicated genome, and …

Chromatin remodeling is central to the dynamic changes in gene expression that drive cell
fate determination. During development, the sets of enhancers that are accessible for use …

Dosage compensation in Drosophila involves upregulating male X-genes two-fold. This
process is carried out by the MSL (male-specific lethal) complex, which binds high-affinity …

Sequencing of human patient tumors has identified recurrent missense mutations in genes
encoding core histones. We report that mutations that convert histone H3 amino acid 50 from …