Preclinical studies have identified glial cells as pivotal players in the genesis and
maintenance of neuropathic pain after nerve injury associated with diabetes, chemotherapy …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Neuropathic pain is one of the most debilitating forms of chronic pain, resulting from an
injury or disease of the somatosensory nervous system, which induces abnormal painful …

Hemoglobin and iron overload is considered the major contributor to intracerebral
hemorrhage (ICH)-induced brain injury. Accumulation of iron in the brain leads to microglia …

The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110
years ago and has been found to play a crucial role in the development of multicellular …

Uveal melanoma (UM), the most common primary intraocular cancer in adults, is among the
tumors with poorer prognosis. Recently, the role of the oncometabolite lactate has become …

Central nervous system (CNS) homeostasis is closely linked to the delicate balance of the
microenvironment in which different cellular components of the neurovascular unit (NVU) …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting
motoneurons (MNs) with a fatal outcome. The typical degeneration of cortico-spinal, spinal …

Although opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common
drugs used in persistent pain treatment; they have shown many side effects. The …

Chronic myeloid leukemia (CML), BCR-ABL1-positive, is classified as a myeloproliferative
characterized by Philadelphia chromosome/translocation t (9; 22) and proliferating …