Vaccination into the dermal compartment: techniques, challenges, and prospects

J Hettinga, R Carlisle - Vaccines, 2020 - mdpi.com
In 2019, an 'influenza pandemic'and 'vaccine hesitancy'were listed as two of the top 10
challenges to global health by the WHO. The skin is a unique vaccination site, due to its …

Recent advances in micro-electro-mechanical devices for controlled drug release applications

LA Villarruel Mendoza, NA Scilletta… - … in Bioengineering and …, 2020 - frontiersin.org
In recent years, controlled release of drugs has posed numerous challenges with the aim of
optimizing parameters such as the release of the suitable quantity of drugs in the right site at …

Immunogenicity of candidate MERS-CoV DNA vaccines based on the spike protein

SS Al-Amri, AT Abbas, LA Siddiq, A Alghamdi… - Scientific reports, 2017 - nature.com
MERS-coronavirus is a novel zoonotic pathogen which spread rapidly to> 25 countries since
2012. Its apparent endemicity and the wide spread of its reservoir host (dromedary camels) …

Synthetic SARS-CoV-2 spike-based DNA vaccine elicits robust and long-lasting th1 humoral and cellular immunity in mice

SS Alamri, KA Alluhaybi, RY Alhabbab… - Frontiers in …, 2021 - frontiersin.org
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) calls for an urgent
development of effective and safe prophylactic and therapeutic measures. The spike (S) …

[HTML][HTML] Strategies for vaccine-product innovation: Creating an enabling environment for product development to uptake in low-and middle-income countries

B Giersing, N Shah, D Kristensen, JP Amorij, AL Kahn… - Vaccine, 2021 - Elsevier
Vaccine-product innovations that address barriers to immunization are urgently needed to
achieve equitable vaccine coverage, as articulated in the new Immunization Agenda 2030 …

In-vitro studies of jet injections

P Rohilla, JO Marston - International journal of pharmaceutics, 2019 - Elsevier
In this study, needle-free jet injection dynamics were studied using homogeneous gelatin as
model substrates. Whilst keeping nozzle properties such as orifice diameter (do) and …

The potential role of using vaccine patches to induce immunity: platform and pathways to innovation and commercialization

K Badizadegan, JL Goodson, PA Rota… - Expert review of …, 2020 - Taylor & Francis
Introduction: In the last two decades, the evidence related to using vaccine patches with
multiple short projections (≤ 1 mm) to deliver vaccines through the skin increased …

Comparison of Immunogenicity and Safety of Diphtheria–Tetanus–Pertussis–Hepatitis B–Haemophilus influenza B (Bio Farma) with Pentabio® Vaccine Primed with …

E Fadlyana, K Rusmil, M Dhamayanti, R Tarigan… - Vaccines, 2023 - mdpi.com
Satisfying the needs of the national immunization program requires maintaining diphtheria–
tetanus–pertussis (DTP)–hepatitis B (HB)–Haemophilus influenza B (Hib) production …

[HTML][HTML] The hypodermic syringe performance based on the ISO 7886-1: 2017: A narrative review

RABR Ghazilla, M Azuddin, MKFBA Hairuddin… - Medicine, 2022 - journals.lww.com
A syringe is used to inject fluid or medicine into the patient's soft tissue. The main
components of the syringe were the needle, barrel, and plunger. The use of syringes in the …

[HTML][HTML] Needleless injectors for the administration of vaccines: a review of clinical effectiveness

C Yu, M Walter - 2020 - ncbi.nlm.nih.gov
A needleless or needle-free jet injector (NFJI) uses a high-pressure stream jet to puncture
the skin surface without using a needle. 1 NFJIs have been used for vaccine or drug …