Redox regulation of the immune response

G Morris, M Gevezova, V Sarafian… - Cellular & Molecular …, 2022 - nature.com
The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

[HTML][HTML] Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation

Y Lu, Z Li, S Zhang, T Zhang, Y Liu, L Zhang - Theranostics, 2023 - ncbi.nlm.nih.gov
Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …

Deubiquitinases in cancer

G Dewson, PJA Eichhorn, D Komander - Nature Reviews Cancer, 2023 - nature.com
Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Akt in cancer: Mediator and more

S Revathidevi, AK Munirajan - Seminars in cancer biology, 2019 - Elsevier
Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

The PI3K pathway in human disease

DA Fruman, H Chiu, BD Hopkins, S Bagrodia… - Cell, 2017 - cell.com
Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …

The functions and regulation of the PTEN tumour suppressor: new modes and prospects

YR Lee, M Chen, PP Pandolfi - Nature reviews Molecular cell biology, 2018 - nature.com
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …

Regulating tumor suppressor genes: post-translational modifications

L Chen, S Liu, Y Tao - Signal transduction and targeted therapy, 2020 - nature.com
Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

The complexity of p53-mediated metabolic regulation in tumor suppression

Y Liu, W Gu - Seminars in cancer biology, 2022 - Elsevier
Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

The regulation of ferroptosis by tumor suppressor p53 and its pathway

J Liu, C Zhang, J Wang, W Hu, Z Feng - International journal of molecular …, 2020 - mdpi.com
Tumor suppressor p53 plays a key role in tumor suppression. In addition to tumor
suppression, p53 is also involved in many other biological and pathological processes, such …

Ubiquitin ligases in oncogenic transformation and cancer therapy

D Senft, J Qi, ZA Ronai - Nature Reviews Cancer, 2018 - nature.com
The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …