Dual-target inhibitors of colchicine binding site for cancer treatment
L Lu, K Li, J Pu, S Wang, T Liang, J Wang - European Journal of Medicinal …, 2024 - Elsevier
Colchicine binding site inhibitors (CBSIs) have attracted much attention due to their
antitumor efficacies and the advantages of inhibiting angiogenesis and overcoming …
antitumor efficacies and the advantages of inhibiting angiogenesis and overcoming …
Scaffold hopping approaches for dual-target antitumor drug discovery: opportunities and challenges
A Mishra, A Thakur, R Sharma, R Onuku… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Scaffold hopping has emerged as a practical tactic to enrich the synthetic bank
of small molecule antitumor agents. Specifically, it enables the chemist to refine the lead …
of small molecule antitumor agents. Specifically, it enables the chemist to refine the lead …
Praeruptorin A screened by a ferrous ion probe inhibited DMT1 and ferroptosis to attenuate Doxorubicin-induced cardiomyopathy
D Li, Y Chen, B Zhang, X Heng, J Yin, P Zhao… - European Journal of …, 2025 - Elsevier
Abstract Doxorubicin (DOX)-induced cardiomyopathy (DIC) greatly limits its clinical
application of the anticancer drug. Therefore, there is an immediate necessity to undertake …
application of the anticancer drug. Therefore, there is an immediate necessity to undertake …
A promising future for breast cancer therapy with hydroxamic acid-based histone deacetylase inhibitors
T Das, S Bhar, D Ghosh, B Kabi, K Kar, A Chandra - Bioorganic Chemistry, 2025 - Elsevier
Histone deacetylases (HDACs) play a critical role in chromatin remodelling and modulating
the activity of various histone proteins. Aberrant HDAC functions has been related to the …
the activity of various histone proteins. Aberrant HDAC functions has been related to the …