Hitting the Sweet Spot: How Glucose Metabolism Is Orchestrated in Space and Time by Phosphofructokinase-1

M Campos, LV Albrecht - Cancers, 2023 - mdpi.com
Simple Summary Glucose metabolism was the first metabolic pathway to be discovered and
serves a central role across all life by generating energy. Cancer cells hijack glycolysis to …

Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations

E Hlavanda, J Kovács, J Oláh, F Orosz… - Biochemistry, 2002 - ACS Publications
Previously, we have demonstrated the presence of a protein factor [tubulin polymerization
perturbing protein (TPPP)] in brain and neuroblastoma cell but not in muscle extract that …

TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation

L Tirián, E Hlavanda, J Oláh, I Horváth… - Proceedings of the …, 2003 - National Acad Sciences
Recently, we isolated from bovine brain a protein, TPPP/p25 and identified as p25, a brain-
specific protein that induced aberrant tubulin assemblies. The primary sequence of this …

Functional aspects of cellular microcompartmentation in the development of neurodegeneration: mutation induced aberrant protein-protein associations

J Ovádi, F Orosz, S Hollán - Molecular and cellular biochemistry, 2004 - Springer
Research in the last 10 years has revealed that the development of neurodegeneration is a
multistep process during which one or few specific mutant protein species of altered …

Alternative binding of two sequential glycolytic enzymes to microtubules: molecular studies in the phosphofructokinase/aldolase/microtubule system

BG Vértessy, F Orosz, J Kovács, J Ovádi - Journal of Biological Chemistry, 1997 - ASBMB
Simultaneous binding of two sequential glycolytic enzymes, phosphofructokinase and
aldolase, to a microtubular network was investigated. The binding of the …

Different involvement for aldolase isoenzymes in kidney glucose metabolism: aldolase B but not aldolase A colocalizes and forms a complex with FBPase

AJ Yañez, HC Ludwig, R Bertinat… - Journal of cellular …, 2005 - Wiley Online Library
The expression of aldolase A and B isoenzyme transcripts was confirmed by RT‐PCR in rat
kidney and their cell distribution was compared with characteristic enzymes of the …

A new level of regulation in gluconeogenesis: metabolic state modulates the intracellular localization of aldolase B and its interaction with liver fructose-1, 6 …

CA Droppelmann, DE Sáez, JL Asenjo… - Biochemical …, 2015 - portlandpress.com
Understanding how glucose metabolism is finely regulated at molecular and cellular levels
in the liver is critical for knowing its relationship to related pathologies, such as diabetes. In …

Epinephrine modulates cellular distribution of muscle phosphofructokinase

GG Alves, M Sola-Penna - Molecular genetics and metabolism, 2003 - Elsevier
In this paper, we report evidences that cellular distribution of phosphofructokinase can be
affected by epinephrine stimulation in rabbit skeletal muscle homogenates. Through co …

Expression of caveolin‐1 in lymphocytes induces caveolae formation and recruitment of phosphofructokinase to the plasma membrane

J Vallejo, CD Hardin - The FASEB journal, 2005 - Wiley Online Library
Compartmentation of carbohydrate metabolism has been shown in a wide range of tissues
including reports of one compartment of glycolysis associated with the plasma membrane of …

Tissue-dependent loss of phosphofructokinase-M in mice with interrupted activity of the distal promoter: impairment in insulin secretion

AMT Richard, DL Webb, JM Goodman… - American Journal …, 2007 - journals.physiology.org
Phosphofructokinase is a key enzyme of glycolysis that exists as homo-and heterotetramers
of three subunit isoforms: muscle, liver, and C type. Mice with a disrupting tag inserted near …