The cellular prion protein (PrP C) is a metal-binding biomolecule that can interact with
different protein partners involved in pivotal physiological processes, such as neurogenesis …

Copper is an essential trace element and possesses critical roles in various brain functions.
A considerable amount of copper accumulates in the synapse and is secreted in neuronal …

The pathogenesis of the various prion diseases is based on the conformational conversion
of the prion protein from its physiological cellular form to the insoluble scrapie isoform …

Alzheimer's disease (AD) is the most common form of dementia worldwide. AD brains are
characterized by the accumulation of amyloid-β peptides (Aβ) that bind Cu2+ and have been …

Water‐soluble melanin‐protein‐Fe/Cu conjugates derived from norepinephrine and fibrillar
β‐lactoglobulin are reliable models for neuromelanin (NM) of human brain locus coeruleus …

We study the interaction between amyloid β (Aβ) peptides and Cu and Zn metal ions by
using soft X-ray absorption spectroscopy. The spectral features of the peptides and Cu are …

Prions have been linked to neurodegenerative diseases that affect various species of
mammals including humans. The prion protein, located mainly in neurons, is believed to …

The trafficking and aggregation of neurodegenerative proteins often involves the interaction
between intrinsically disordered domains, stabilized by the inclusion of physiologic metal …

The prion protein (PrP) is a metal binding protein that plays multifunctional roles in the brain
and it is associated with spongiform encephalopathy disorders, a group of …

It is estimated that 50 million individuals worldwide live with Alzheimer's disease (AD), a
neurodegenerative progressive disorder that, along with other chronic dementias, cost the …