Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

The adaptive transition of glioblastoma stem cells and its implications on treatments

Z Wang, H Zhang, S Xu, Z Liu, Q Cheng - Signal transduction and …, 2021 - nature.com
Glioblastoma is the most malignant tumor occurring in the human central nervous system
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …

A mosaic world: puzzles revealed by adult neural stem cell heterogeneity

Z Chaker, P Codega, F Doetsch - Wiley Interdisciplinary …, 2016 - Wiley Online Library
Neural stem cells (NSCs) reside in specialized niches in the adult mammalian brain. The
ventricular–subventricular zone (V‐SVZ), adjacent to the lateral ventricles, gives rise to …

Regulating endogenous neural stem cell activation to promote spinal cord injury repair

EAB Gilbert, N Lakshman, KSK Lau, CM Morshead - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure,
and treatment options to promote neural recovery are limited. An innovative approach to …

Emerging intersections between neuroscience and glioma biology

E Jung, J Alfonso, M Osswald, H Monyer, W Wick… - Nature …, 2019 - nature.com
The establishment of neuronal and glial networks in the brain depends on the activities of
neural progenitors, which are influenced by cell-intrinsic mechanisms, interactions with the …

Radiation-induced brain injury: age dependency of neurocognitive dysfunction following radiotherapy

CE Rübe, S Raid, J Palm, C Rübe - Cancers, 2023 - mdpi.com
Simple Summary Radiation therapy-related brain damage with neurocognitive impairment is
a common long-term side effect in cancer survivors and significantly impairs the quality of …

The organism as the niche: physiological states crack the code of adult neural stem cell heterogeneity

Z Chaker, E Makarouni, F Doetsch - Annual Review of Cell and …, 2024 - annualreviews.org
Neural stem cells (NSCs) persist in the adult mammalian brain and are able to give rise to
new neurons and glia throughout life. The largest stem cell niche in the adult mouse brain is …

Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module

Y Harada, M Yamada, I Imayoshi, R Kageyama… - Nature …, 2021 - nature.com
Quiescent neural stem cells (NSCs) in the adult mouse brain are the source of neurogenesis
that regulates innate and adaptive behaviors. Adult NSCs in the subventricular zone are …

[HTML][HTML] Cognitive effects of low dose of ionizing radiation–Lessons learned and research gaps from epidemiological and biological studies

E Pasqual, F Boussin, D Bazyka, A Nordenskjold… - Environment …, 2021 - Elsevier
The last decades have seen increased concern about the possible effects of low to
moderate doses of ionizing radiation (IR) exposure on cognitive function. An interdisciplinary …

Distinct molecular signatures of quiescent and activated adult neural stem cells reveal specific interactions with their microenvironment

L Morizur, A Chicheportiche, LR Gauthier, M Daynac… - Stem cell reports, 2018 - cell.com
Deciphering the mechanisms that regulate the quiescence of adult neural stem cells (NSCs)
is crucial for the development of therapeutic strategies based on the stimulation of their …