[HTML][HTML] MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases

H Zhou, Y He, W Xiong, S Jing, X Duan, Z Huang… - Bioactive materials, 2023 - Elsevier
Mesenchymal stem cells (MSCs) are promising seed cells for neural regeneration therapy
owing to their plasticity and accessibility. They possess several inherent characteristics …

Nose-to-Brain: The Next Step for Stem Cell and Biomaterial Therapy in Neurological Disorders

N Villar-Gómez, DD Ojeda-Hernandez… - Cells, 2022 - mdpi.com
Neurological disorders are a leading cause of morbidity worldwide, giving rise to a growing
need to develop treatments to revert their symptoms. This review highlights the great …

Brain aging and Parkinson's disease: New therapeutic approaches using drug delivery systems

C Rodríguez-Nogales, E Garbayo… - Maturitas, 2016 - Elsevier
The etiology and pathogenesis of Parkinson's disease (PD) is unknown, aging being the
strongest risk factor for brain degeneration. Understanding PD pathogenesis and how aging …

Sleeping Beauty transposon system for GDNF overexpression of entrapped stem cells in fibrin hydrogel in a rat model of Parkinson's disease

L Stahn, J Rasińska, T Dehne, S Schreyer… - Drug Delivery and …, 2023 - Springer
There is currently no causal treatment available for Parkinson's disease (PD). However, the
use of glial cell line–derived neurotrophic factor (GDNF) to provide regenerative effects for …

Natural biomaterials in brain repair: A focus on collagen

B Ucar - Neurochemistry international, 2021 - Elsevier
Biomaterials derived from natural resources have increasingly been used for versatile
applications in the central nervous system (CNS). Thanks to their biocompatibility and …

Efficient cholera toxin B subunit‐based nanoparticles with MRI capability for drug delivery to the brain following intranasal administration

Y Chen, H Fan, C Xu, W Hu, B Yu - Macromolecular bioscience, 2019 - Wiley Online Library
Alzheimer's disease (AD) is an incurable neurodegenerative brain disorder that exhibits
clear pathologic changes in the hippocampus. Traditional drug delivery systems are …

Bidirectional Enzyme Inhibition and Activation for In Situ Formation of Injectable Hydrogel Using a Bispecific Aptamer

C Wen, K Lee, Y Wang, X Wang, Y Wang - Langmuir, 2024 - ACS Publications
In situ injectable hydrogels have been explored for biomedical applications, including
regenerative medicine and drug delivery. However, controlling the kinetics of their gelation …

Mesenchymal stromal cell biotherapy for Parkinson's disease premotor symptoms

J Sun, W Zhang, ZZ Wei, X Song, L Jian… - Chinese …, 2023 - mednexus.org
Parkinson's disease (PD) is a neurodegenerative disorder with motor deficits due to
nigrostriatal dopamine depletion and with the non-motor/premotor symptoms (NMS) such as …

Hydrogel-Based Strategies for Stem Cell Therapy

S Zhang, Y Nie, H Tao, Z Li - Hydrogels: Recent Advances, 2018 - Springer
Stem cells from different sources provide considerable expectation for applications in tissue
engineering and regenerative medicine because of their ability to proliferate and …

[PDF][PDF] Современные технологии культивирования стволовых клеток головного мозга

ЮК Комлева, ЕД Осипова, АВ Моргун… - Цитология, 2018 - tsitologiya.incras.ru
В обзоре описаны характеристики нейрональных стволовых клеток, особенности
формирования нейрогенных ниш во взрослом головном мозге, а также рассмотрены …