Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

R-loops are three-stranded nucleic acid structures that are abundant and widespread across
the genome and that have important physiological roles in many nuclear processes. Their …

During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …

Double-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired,
may lead to genome instability or cell death. Here, we report that, in response to DSBs, the …

R-loops are non-B DNA structures with intriguing dual consequences for gene expression
and genome stability. In addition to their recognized roles in triggering DNA double-strand …

Given that genomic DNA exerts its function by being transcribed, it is critical for the
maintenance of homeostasis that DNA damage, such as double-strand breaks (DSBs) …

Damage-induced long non-coding RNAs (dilncRNA) synthesized at DNA double-strand
breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus …

Exosome cargoes are highly varied and include proteins, small RNAs, and genomic DNA
(gDNA). The presence of gDNA suggests that different intracellular compartments contribute …

DNA double-strand breaks (DSBs) are toxic DNA lesions, which, if not properly repaired,
may lead to genomic instability, cell death and senescence. Damage-induced long non …