Apoptotic cell death is widely considered a positive process that both prevents and treats
cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also …

Cell death plays an essential role in the development of tissues and organisms, the etiology
of disease, and the responses of cells to therapeutic drugs. Here we review progress made …

Tissue development and homeostasis are regulated by opposing pro-survival and pro-death
signals. An interesting feature of the Tumor Necrosis Factor (TNF) family of ligands is that …

When cells are exposed to death ligands such as TRAIL, a fraction undergoes apoptosis
and a fraction survives; if surviving cells are re‐exposed to TRAIL, fractional killing is once …

Essentially, all metazoan cells can undergo apoptosis, but some cells are more sensitive
than others to apoptotic stimuli. To date, it is unclear what determines the apoptotic potential …

Genetically encoded biosensors based on fluorescent proteins (FPs) allow for the real-time
monitoring of molecular dynamics in space and time, which are crucial for the proper …

Abstract Cytosolic caspase-3-like proteases, such as caspase-3 and caspase-7, have a
central role in mediating the progress of apoptosis. Here to conveniently monitor caspase-3 …

Apoptosis is the best described form of regulated cell death, and was, until relatively
recently, considered irreversible once particular biochemical points-of-no-return were …

Antiapoptotic Bcl-2 family proteins are often highly expressed in chemotherapy-resistant
cancers and impair mitochondrial outer membrane permeabilisation (MOMP), an important …

Chronic inhalation of crystalline silica is an occupational hazard that results in silicosis due
to the toxicity of silica particles to lung cells. Alveolar macrophages play an important role in …