Glycomimetics for the inhibition and modulation of lectins

S Leusmann, P Ménová, E Shanin, A Titz… - Chemical Society …, 2023 - pubs.rsc.org
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands

S Cecioni, A Imberty, S Vidal - Chemical reviews, 2015 - ACS Publications
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …

From carbohydrate leads to glycomimetic drugs

B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …

Glycopolymer probes of signal transduction

LL Kiessling, JC Grim - Chemical Society Reviews, 2013 - pubs.rsc.org
Glycans are key participants in biological processes ranging from reproduction to cellular
communication to infection. Revealing glycan roles and the underlying molecular …

Targeting C-type lectin receptors with multivalent carbohydrate ligands

B Lepenies, J Lee, S Sonkaria - Advanced drug delivery reviews, 2013 - Elsevier
C-type lectin receptors (CLRs) represent a large receptor family including collectins,
selectins, lymphocyte lectins, and proteoglycans. CLRs share a structurally homologous …

Grading the commercial optical biosensor literature—Class of 2008:'The Mighty Binders'

RL Rich, DG Myszka - Journal of Molecular Recognition: An …, 2010 - Wiley Online Library
Optical biosensor technology continues to be the method of choice for label‐free, real‐time
interaction analysis. But when it comes to improving the quality of the biosensor literature …

DC-SIGN neck domain is a pH-sensor controlling oligomerization: SAXS and hydrodynamic studies of extracellular domain

G Tabarani, M Thépaut, D Stroebel, C Ebel… - Journal of Biological …, 2009 - ASBMB
DC-SIGN is a C-type lectin receptor of dendritic cells and is involved in the early stages of
numerous infectious diseases. DC-SIGN is organized into a tetramer enabling multivalent …

Inhibition of DC-SIGN-mediated HIV infection by a linear trimannoside mimic in a tetravalent presentation

S Sattin, A Daghetti, M Thepaut, A Berzi… - ACS chemical …, 2010 - ACS Publications
HIV infection is pandemic in humans and is responsible for millions of deaths every year.
The discovery of new cellular targets that can be used to prevent the infection process …

[图书][B] Animal lectins: form, function and clinical applications

GS Gupta - 2012 - books.google.com
Animal Lectins: Form, Function and Clinical Applications presents up-to-date knowledge of
animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular …

Systematic dual targeting of dendritic cell C-type lectin receptor DC-SIGN and TLR7 using a trifunctional mannosylated antigen

RJE Li, TP Hogervorst, S Achilli, SC Bruijns… - Frontiers in …, 2019 - frontiersin.org
Dendritic cells (DCs) are important initiators of adaptive immunity, and they possess a
multitude of Pattern Recognition Receptors (PRR) to generate an adequate T cell mediated …