Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum
based therapy, the standard care for primary ovarian cancer management. A deeper …

Microtubules are highly dynamic structures, which consist of α-and β-tubulin heterodimers,
and are involved in cell movement, intracellular trafficking, and mitosis. In the context of …

Microtubules are dynamic structures composed of α–β-tubulin heterodimers that are
essential in cell division and are important targets for cancer drugs. Mutations in β-tubulin …

Abstract Taxanes (Taxol/paclitaxel, Docetaxel/taxotere) are a key group of successful drugs
commonly used in chemotherapy to treat several major malignant tumors also as a front-line …

Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …

Microtubules are important cellular targets for anticancer therapy because of their key role in
mitosis. Microtubule inhibitors (MTI) such as taxanes, vinca alkaloids, and epothilones …

The taxanes, paclitaxel and docetaxel are microtubule-stabilizing agents that function
primarily by interfering with spindle microtubule dynamics causing cell cycle arrest and …

Introduction: Paclitaxel and docetaxel were two epoch-making anticancer drugs and have
been successfully used in chemotherapy for a variety of cancer types. In the year 2010, a …

Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

The β‐tubulins are microtubule components encoded by a multigene family, which produces
slightly different proteins with complex expression patterns. Several widely used anticancer …