Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets

L Badimon, T Padro, G Arderiu, G Vilahur… - Immunological …, 2022 - Wiley Online Library
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of global
mortality. Extracellular vesicles (EVs) are small phospholipid vesicles that convey molecular …

Extracellular vesicles as mediators of neuroinflammation in intercellular and inter-organ crosstalk

A Cabrera-Pastor - International Journal of Molecular Sciences, 2024 - mdpi.com
Neuroinflammation, crucial in neurological disorders like Alzheimer's disease, multiple
sclerosis, and hepatic encephalopathy, involves complex immune responses. Extracellular …

Stroke proteomics: from discovery to diagnostic and therapeutic applications

K Hochrainer, W Yang - Circulation research, 2022 - Am Heart Assoc
Stroke remains a leading cause of death and disability, with limited therapeutic options and
suboptimal tools for diagnosis and prognosis. High throughput technologies such as …

Extracellular vesicles as drivers of immunoinflammation in atherothrombosis

R Suades, MF Greco, T Padró, L Badimon - Cells, 2022 - mdpi.com
Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality all
over the world. Extracellular vesicles (EVs), small lipid-bilayer membrane vesicles released …

Extracellular vesicle-mediated bidirectional communication between heart and other organs

K Gabisonia, M Khan… - American Journal of …, 2022 - journals.physiology.org
In recent years, a wealth of studies has identified various molecular species released by
cardiac muscle under physiological and pathological conditions that exert local paracrine …

Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke

M Wang, Y Peng - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Neurocardiology is an emerging field that studies the interaction between the brain and the
heart, namely the effects of heart injury on the brain and the effects of brain damage on the …

Extracellular vesicles in atherothrombosis and cardiovascular disease: friends and foes

O Giró, A Jiménez, A Pané, L Badimon, E Ortega… - Atherosclerosis, 2021 - Elsevier
Extracellular vesicles (EV, exosomes and microvesicles-MV-) are 30–1000 nm particles
surrounded by a phospholipid bilayer membrane that are released from almost all cell types …

Circulating extracellular vesicle proteins and microRNA profiles in subcortical and cortical-subcortical ischaemic stroke

L Otero-Ortega, E Alonso-López, M Pérez-Mato… - Biomedicines, 2021 - mdpi.com
In order to investigate the role of circulating extracellular vesicles (EVs), proteins, and
microRNAs as damage and repair markers in ischaemic stroke depending on its …

Inflammatory Response and Immune Regulation in Brain‐Heart Interaction after Stroke

L Zou, R Han - Cardiovascular Therapeutics, 2022 - Wiley Online Library
Cerebrocardiac syndrome (CCS) is one of the secondary myocardial injuries after stroke.
Cerebrocardiac syndrome may result in a poor prognosis with high mortality. Understanding …

Risk stratification of patients with SARS-CoV-2 by tissue factor expression in circulating extracellular vesicles

J Burrello, E Caporali, LG Gauthier, E Pianezzi… - Vascular …, 2022 - Elsevier
Inflammatory response following SARS-CoV-2 infection results in substantial increase of
amounts of intravascular pro-coagulant extracellular vesicles (EVs) expressing tissue factor …