Leishmaniasis is a vector-borne neglected tropical disease associated with a spectrum of
clinical manifestations, ranging from self-healing cutaneous lesions to fatal visceral …

Highlights•Kinetoplastids do not control transcription of individual protein-coding
genes.•mRNAs are made from polycistronic precursors by trans splicing and …

Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …

Leishmania parasites alternate between extracellular promastigote stages in the insect
vector and an obligate intracellular amastigote stage that proliferates within the …

The protozoan parasite Leishmania possesses a single flagellum, which is remodelled
during the parasite's life cycle from a long motile flagellum in promastigote forms in the sand …

While gene expression is a fundamental and tightly controlled cellular process that is
regulated at multiple steps, the exact contribution of each step remains unknown in any …

The unfolded protein response (UPR) is a network of signaling pathways that responds to
stress in the endoplasmic reticulum (ER). The general output of the UPR is to upregulate …

Information on the growth rate and metabolism of microbial pathogens that cause long-term
chronic infections is limited, reflecting the absence of suitable tools for measuring these …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

Leishmania spp. are sandfly-transmitted parasitic protozoa that cause a spectrum of
important diseases and lifelong chronic infections in humans. In the mammalian host, these …