Microglia are resident macrophages of the CNS that are involved in its development,
homeostasis and response to infection and damage. Microglial activation is a common …

Drug repurposing holds the potential to bring medications with known safety profiles to new
patient populations. Numerous examples exist for the identification of new indications for …

Multiple sclerosis is characterized by inflammatory activity that results in destruction of the
myelin sheaths that enwrap axons. The currently available medications for multiple sclerosis …

The amyloid hypothesis (AH) of Alzheimer's disease (AD) posits that the fundamental cause
of AD is the accumulation of the peptide amyloid beta (Aβ) in the brain. This hypothesis has …

Multiple lines of evidence in schizophrenia, from brain imaging, studies in postmortem
brains, and genetic association studies, have implicated oligodendrocyte and myelin …

Background–Important advances in multiple sclerosis (MS) research have been made as a
direct or indirect result of experiments in animal models for the disease, although MS is a …

BackgroundOur understanding of the complex relationship between schizophrenia
symptomatology and etiological factors can be improved by studying brain-based correlates …

Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease
characterized by myelin damage followed by axonal and ultimately neuronal loss. The …

The cuprizone model of toxic demyelination in the central nervous system is commonly used
to investigate the pathobiology of remyelination in the corpus callosum. However, in human …

Antipsychotics represent the mainstay of schizophrenia pharmacological therapy, and their
role has been expanded in the last years to mood disorders treatment. Although introduced …