Adverse neuropsychiatric events and recreational use of efavirenz and other HIV-1 antiretroviral drugs
Efavirenz is a highly effective HIV-1 antiretroviral; however, it is also frequently associated
with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep …
with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep …
Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions
Early identification of genetic risk factors for complex diseases can enable timely
interventions and prevent serious outcomes, including mortality. While the genetics …
interventions and prevent serious outcomes, including mortality. While the genetics …
Inconsistency in race and ethnic classification in pharmacogenetics studies and its potential clinical implications
F Zhang, J Finkelstein - Pharmacogenomics and personalized …, 2019 - Taylor & Francis
Introduction Racial and ethnic categories are frequently used in pharmacogenetics literature
to stratify patients; however, these categories can be inconsistent across different studies. To …
to stratify patients; however, these categories can be inconsistent across different studies. To …
Phage biobank: present challenges and future perspectives
After a century of use in human infection, the preparation and administration of therapeutic
bacteriophages (phages) still relies on ad hoc partnerships of researchers, biotech …
bacteriophages (phages) still relies on ad hoc partnerships of researchers, biotech …
The success of pharmacogenomics in moving genetic association studies from bench to bedside: study design and implementation of precision medicine in the post …
MD Ritchie - Human genetics, 2012 - Springer
Pharmacogenomics is emerging as a popular type of study for human genetics in recent
years. This is primarily due to the many success stories and high potential for translation to …
years. This is primarily due to the many success stories and high potential for translation to …
[PDF][PDF] Barriers to Implementing Clinical Pharmacogenetics Testing in Sub-Saharan Africa. A Critical Review.
Clinical research in high-income countries is increasingly demonstrating the
costeffectiveness of clinical pharmacogenetic (PGx) testing in reducing the incidence of …
costeffectiveness of clinical pharmacogenetic (PGx) testing in reducing the incidence of …
Is universal health coverage the practical expression of the right to health care?
Abstract The present Millennium Development Goals are set to expire in 2015 and their next
iteration is now being discussed within the international community. With regards to health …
iteration is now being discussed within the international community. With regards to health …
Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects
A Matimba, J Del-Favero, C Van Broeckhoven… - Human genomics, 2009 - Springer
Pharmacogenetics enables personalised therapy based on genetic profiling and is
increasingly applied in drug discovery. Medicines are developed and used together with …
increasingly applied in drug discovery. Medicines are developed and used together with …
Pharmacokinetics of tamoxifen and its major metabolites and the effect of the African ancestry specific CYP2D6* 17 variant on the formation of the active metabolite …
CR Kanji, G Nyabadza, C Nhachi… - Journal of personalized …, 2023 - mdpi.com
Tamoxifen (TAM) is widely used in the treatment of hormone receptor-positive breast cancer.
TAM is metabolized into the active secondary metabolite endoxifen (ENDO), primarily by …
TAM is metabolized into the active secondary metabolite endoxifen (ENDO), primarily by …
Pharmacogenomic research in South Africa: lessons learned and future opportunities in the rainbow nation
South Africa, like many other developing countries, stands to benefit from novel diagnostics
and drugs developed by pharmacogenomics guidance due to high prevalence of disease …
and drugs developed by pharmacogenomics guidance due to high prevalence of disease …