Ulcerative colitis and Crohn's disease are a set of chronic, idiopathic, immunological and
relapsing inflammatory disorders of the gastrointestinal tract referred to as inflammatory …

Oxidative stress (OS) is considered as one of the etiologic factors involved in several signals
and symptoms of inflammatory bowel diseases (IBD) that include diarrhea, toxic megacolon …

Background Despite recent advances the pathogenesis of Crohn's disease remains
incompletely understood. A variety of animal models have been utilized in an effort to …

Aims The present study aimed to investigate the effect of nano selenium, sildenafil, and their
combination on inflammation, oxidative stress, and apoptosis in streptozotocin-induced …

Sildenafil, approved two decades ago, is the inhibitor of phosphodiesterase 5 (PDE5). First
of all, it was designated for angina pectoris, but soon it showed a wonderful efficacy in …

Abstract Phosphodiesterase 5 (PDE-5) is a major isoform of cGMP phosphodiesterase in
diverse tissues and plays a critical role in regulating intracellular cGMP concentrations …

Methylsulfonylmethane (MSM), naturally occurring in green plants, fruits and vegetables,
has been shown to exert anti-inflammatory and antioxidant effects. MSM is an organosulfur …

The pathogenesis of ulcerative colitis (UC), a chronic intestine inflammatory disease
primarily affecting adolescents, remains uncertain. Contemporary studies suggest that a …

Background Cyclic neucleotides are involved in many cellular functions including smooth
muscle relaxation, inflammation, and signal transduction. Sildenafil and tadalafil are …

Severe burn induces biochemical mediators such as reactive oxygen species that leads to
lipid peroxidation which may have a key role in formation of acute lung injury (ALI). Sildenafil …