The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge

G Heusch, BJ Gersh - European heart journal, 2017 - academic.oup.com
The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

DJ Hausenloy, DM Yellon - The Journal of clinical …, 2013 - Am Soc Clin Investig
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In
patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and …

Coronary microvascular obstruction in acute myocardial infarction

G Niccoli, G Scalone, A Lerman… - European heart …, 2016 - academic.oup.com
The success of a primary percutaneous intervention (PCI) in the setting of ST elevation
myocardial infarction depends on the functional and structural integrity of coronary …

Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology

DJ Hausenloy, HE Bøtker, G Condorelli… - Cardiovascular …, 2013 - academic.oup.com
Coronary heart disease (CHD) is the leading cause of death and disability worldwide.
Despite current therapy, the morbidity and mortality for patients with CHD remains …

Signaling pathways in cardiac myocyte apoptosis

P Xia, Y Liu, Z Cheng - BioMed research international, 2016 - Wiley Online Library
Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches

DJ Van Veldhuisen, SD Anker, P Ponikowski… - Nature Reviews …, 2011 - nature.com
Anemia and iron deficiency are common in patients with heart failure (HF), and are
associated with worse symptoms and adverse outcomes in this population. Although the two …

The therapeutic potential of ischemic conditioning: an update

DJ Hausenloy, DM Yellon - Nature Reviews Cardiology, 2011 - nature.com
Novel approaches are required to improve clinical outcomes in patients with coronary heart
disease (CHD). Ischemic conditioning—the practice of applying brief episodes of nonlethal …

Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial

SS Najjar, SV Rao, C Melloni, SV Raman, TJ Povsic… - Jama, 2011 - jamanetwork.com
Context Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of
morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and …

Cardioprotection during cardiac surgery

DJ Hausenloy, E Boston-Griffiths… - Cardiovascular …, 2012 - academic.oup.com
Coronary heart disease (CHD) is the leading cause of morbidity and mortality worldwide. For
a large number of patients with CHD, coronary artery bypass graft (CABG) surgery remains …

Current state of clinical translation of cardioprotective agents for acute myocardial infarction

RA Kloner - Circulation research, 2013 - Am Heart Assoc
There is continued interest in the concept of limiting myocardial infarct size with adjunctive
agents administered along with reperfusion injury; however, there remains considerable …