Unveiling the future of metabolic medicine: omics technologies driving personalized solutions for precision treatment of metabolic disorders

S Singh, DK Sarma, V Verma, R Nagpal… - … and Biophysical Research …, 2023 - Elsevier
Metabolic disorders are increasingly prevalent worldwide, leading to high rates of morbidity
and mortality. The variety of metabolic illnesses can be addressed through personalized …

Synthesis of bioactive oligosaccharides and their potential health benefits

Y Chen, Y Wen, Y Zhu, Z Chen, W Mu… - Critical Reviews in Food …, 2024 - Taylor & Francis
Oligosaccharides, a low polymerization degree of carbohydrate, possess various
physiological activities, such as anti-diabetes, anti-obesity, anti-aging, anti-viral, and gut …

Effects of tirzepatide, a dual GIP and GLP-1 RA, on lipid and metabolite profiles in subjects with type 2 diabetes

V Pirro, KD Roth, Y Lin, JA Willency… - The Journal of …, 2022 - academic.oup.com
Context Tirzepatide substantially reduced hemoglobin A1c (HbA1c) and body weight in
subjects with type 2 diabetes (T2D) compared with the glucagon-like peptide 1 receptor …

A metabolic pattern in healthy subjects given a single dose of metformin: a metabolomics approach

LA Dahabiyeh, M Mujammami, T Arafat… - Frontiers in …, 2021 - frontiersin.org
Metformin is a widely prescribed medication for the treatment of type 2 diabetes mellitus
(T2DM). It possesses effective roles in various disorders, including cancer, dyslipidemia, and …

A distinctive human metabolomics alteration associated with osteopenic and osteoporotic patients

SM Aleidi, EA Alnehmi, M Alshaker, A Masood… - Metabolites, 2021 - mdpi.com
Osteoporosis is a common progressive metabolic bone disease resulting in decreased bone
mineral density (BMD) and a subsequent increase in fracture risk. The known bone markers …

Metabolomic and genetic architecture of gestational diabetes subtypes

K Lee, A Kuang, JR Bain, MG Hayes, MJ Muehlbauer… - Diabetologia, 2024 - Springer
Aims/hypothesis Physiological gestational diabetes mellitus (GDM) subtypes that may confer
different risks for adverse pregnancy outcomes have been defined. The aim of this study was …

E. coli Secretome Metabolically Modulates MDA-MB-231 Breast Cancer Cells' Energy Metabolism

RH AlMalki, R Sebaa, MM Al-Ansari… - International Journal of …, 2023 - mdpi.com
Breast cancer (BC) is commonly diagnosed in women. BC cells are associated with altered
metabolism, which is essential to support their energetic requirements, cellular proliferation …

Lipids alterations associated with metformin in healthy subjects: an investigation using mass spectrometry shotgun approach

LA Dahabiyeh, M Mujammami, RH AlMalki… - International Journal of …, 2022 - mdpi.com
Metformin is an orally effective insulin-sensitizing drug widely prescribed for treating type 2
diabetes mellitus (T2DM). Metformin has been reported to alter lipid metabolism. However …

Metabolomics and lipidomics signatures of insulin resistance and abdominal fat depots in people living with obesity

YC Koay, ACF Coster, DL Chen, B Milner, A Batarseh… - Metabolites, 2022 - mdpi.com
The liver, skeletal muscle, and adipose tissue are major insulin target tissues and key
players in glucose homeostasis. We and others have described diverse insulin resistance …

Metabolomics and metabolites in ischemic stroke

MS Chumachenko, TV Waseem… - Reviews in the …, 2022 - degruyter.com
Stroke is a major reason for disability and the second highest cause of death in the world.
When a patient is admitted to a hospital, it is necessary to identify the type of stroke, and the …