Patients with diabetes mellitus have> 2× the risk for developing heart failure (HF; HF with
reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular …

Cell proliferation, apoptosis, autophagy, oxidative stress and metabolic dysregulation are
the basis of many diseases. Forkhead box transcription factor O1 (FOXO1) changes in …

The studies of psychedelics, especially psychedelic tryptamines like psilocybin, are rapidly
gaining interest in neuroscience research. Much of this interest stems from recent clinical …

Aims This study aimed to investigate the effects of resveratrol (3, 4′, 5-trihydroxystilbene,
RES) on osteoporosis and the role of SIRT1/FoxO1 pathway in the process. Main methods In …

The peptide hormone insulin is a key regulator of energy metabolism, proliferation and
survival. Binding of insulin to its receptor activates the PI3K/AKT signalling pathway, which …

Fibrosis is a universally age-related disease that involves nearly all organs. It is typically
initiated by organic injury and eventually results in organ failure. There are still few effective …

Forkhead box-O1 (FOXO1) is a downstream target of AKT and plays crucial roles in cell
cycle control, apoptosis, metabolism and adipocyte differentiation. It is thought that FOXO1 …

The combined derangements in mitochondria network, function and dynamics can affect
metabolism and ATP production, redox homeostasis and apoptosis triggering, contributing …

Normal tension glaucoma (NTG) is referred to as a progressive degenerative disorder of the
retinal ganglion cells (RGCs), resulting in nonreversible visual defects, despite intraocular …

Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million
deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) …