Epigenetic protein families: a new frontier for drug discovery
Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …
establishes normal cellular phenotypes but also contributes to human diseases. At the …
Inhibitors of protein methyltransferases and demethylases
Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …
histone demethylases (KDMs) play an important role in the regulation of gene expression …
Hyperglycemia as a risk factor for cancer progression
TY Ryu, J Park, PE Scherer - Diabetes & metabolism journal, 2014 - synapse.koreamed.org
As the prevalence of diabetes mellitus is substantially increasing worldwide, associated
diseases such as renal failure, cardiovascular diseases, fatty liver, and cancers have also …
diseases such as renal failure, cardiovascular diseases, fatty liver, and cancers have also …
Diabetes and cancer: a review of current knowledge
J Wojciechowska, W Krajewski… - Experimental and …, 2016 - thieme-connect.com
Diabetes mellitus (DM), one of the most common life-threatening illnesses worldwide, is a
group of metabolic diseases, characterized by sustained hyperglycemia. The global …
group of metabolic diseases, characterized by sustained hyperglycemia. The global …
Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives
FI Milagro, ML Mansego, C De Miguel… - Molecular aspects of …, 2013 - Elsevier
Nutritional factors play a life-long role in human health. Indeed, there is growing evidence
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …
Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells
FM Drawnel, S Boccardo, M Prummer, F Delobel… - Cell reports, 2014 - cell.com
Diabetic cardiomyopathy is a complication of type 2 diabetes, with known contributions of
lifestyle and genetics. We develop environmentally and genetically driven in vitro models of …
lifestyle and genetics. We develop environmentally and genetically driven in vitro models of …
Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships
Abstract Changes in epigenetic marks such as DNA methylation and histone acetylation are
associated with a broad range of disease traits, including cancer, asthma, metabolic …
associated with a broad range of disease traits, including cancer, asthma, metabolic …
The endothelium: influencing vascular smooth muscle in many ways
CR Triggle, SM Samuel, S Ravishankar… - Canadian journal of …, 2012 - cdnsciencepub.com
The endothelium, although only a single layer of cells lining the vascular and lymphatic
systems, contributes in multiple ways to vascular homeostasis. Subsequent to the 1980 …
systems, contributes in multiple ways to vascular homeostasis. Subsequent to the 1980 …
[HTML][HTML] Challenges and perspectives in the treatment of diabetes associated breast cancer
Type 2 diabetes mellitus is one of the most common chronic disease worldwide and affects
all cross-sections of the society including children, women, youth and adults. Scientific …
all cross-sections of the society including children, women, youth and adults. Scientific …
Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy
Q Zhong, RA Kowluru - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE To investigate the role of epigenetic regulation of the manganese superoxide
dismutase gene (sod2) in the development of diabetic retinopathy and the metabolic …
dismutase gene (sod2) in the development of diabetic retinopathy and the metabolic …