The choriocapillaris is the innermost structure of the choroid that directly nourishes the
retinal pigment epithelium and photoreceptors. This article provides an overview of its …

AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …

The three interacting components of the outer blood-retinal barrier are the retinal pigment
epithelium (RPE), choriocapillaris, and Bruch's membrane, the extracellular matrix that lies …

Optical coherence tomography angiography (OCTA) has transformed ocular vascular
imaging, revealing microvascular changes linked to various systemic diseases. This review …

Purpose Type 1 macular neovascularization (MNV) secondary to age-related macular
degeneration (AMD) may sustain hypoxic and micronutrient-insufficient outer retinal cells …

AMD pathobiology was irreversibly changed by the recent discovery of extracellular
cholesterol-containing deposits in the subretinal space, between the photoreceptors and …

The pachychoroid disease spectrum (PDS) includes several chorioretinal diseases that
share specific choroidal abnormalities. Although their pathophysiological basis is poorly …

The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of
chorioretinal diseases, many of which are poorly understood. Recent advances in the field of …

Evidence from histopathology and clinical imaging suggest that choroidal anatomy and
hemodynamic perfusion are among the earliest changes in retinal diseases such as age …

Diabetes induces lesions of the retinal and choroidal capillaries, which promote the
pathogenesis of diabetic retinopathy (DR). The decorrelation signals in optical coherence …