CXCR4 and CXCR7 signaling pathways: a focus on the cross-talk between cancer cells and tumor microenvironment
S Santagata, C Ieranò, AM Trotta, A Capiluongo… - Frontiers in …, 2021 - frontiersin.org
The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors
(GPCRs) activated through their shared ligand CXCL12 in multiple human cancers. They …
(GPCRs) activated through their shared ligand CXCL12 in multiple human cancers. They …
Emerging strategies in TCR-engineered T cells
Immunotherapy of cancer has made tremendous progress in recent years, as demonstrated
by the remarkable clinical responses obtained from adoptive cell transfer (ACT) of patient …
by the remarkable clinical responses obtained from adoptive cell transfer (ACT) of patient …
TCR redirected T cells for cancer treatment: achievements, hurdles, and goals
F Manfredi, BC Cianciotti, A Potenza, E Tassi… - Frontiers in …, 2020 - frontiersin.org
Adoptive T cell therapy (ACT) is a rapidly evolving therapeutic approach designed to
harness T cell specificity and function to fight diseases. Based on the evidence that T …
harness T cell specificity and function to fight diseases. Based on the evidence that T …
CD58 loss in tumor cells confers functional impairment of CAR T cells
X Yan, D Chen, X Ma, Y Wang, Y Guo, J Wei… - Blood …, 2022 - ashpublications.org
Chimeric antigen receptor (CAR) T-cell therapy has achieved significant success in treating
a variety of hematologic malignancies, but resistance to this treatment in some patients …
a variety of hematologic malignancies, but resistance to this treatment in some patients …
Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline
Aging is a major risk factor for the development of nervous system functional decline, even in
the absence of diseases or trauma. The axon–myelin units and synaptic terminals are some …
the absence of diseases or trauma. The axon–myelin units and synaptic terminals are some …
Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness
S Isringhausen, YV Mun, L Kovtonyuk… - Journal of Experimental …, 2021 - rupress.org
Chronic viral infections are associated with hematopoietic suppression, bone marrow (BM)
failure, and hematopoietic stem cell (HSC) exhaustion. However, how persistent viral …
failure, and hematopoietic stem cell (HSC) exhaustion. However, how persistent viral …
Personalized neoantigen vaccines as early intervention in untreated patients with lymphoplasmacytic lymphoma: a non-randomized phase 1 trial
Lymphoplasmacytic lymphoma (LPL) is an incurable low-grade lymphoma with no standard
therapy. Nine asymptomatic patients treated with a first-in-human, neoantigen DNA vaccine …
therapy. Nine asymptomatic patients treated with a first-in-human, neoantigen DNA vaccine …
[HTML][HTML] Target selection of CAR T cell therapy in accordance with the TME for solid tumors
B Liu, L Yan, M Zhou - American journal of cancer research, 2019 - ncbi.nlm.nih.gov
Chimeric antigen receptor-engineered T (CAR T) cell therapy has made great progress in
hematological malignancies and resulted in two newly FDA-approved drugs specific for …
hematological malignancies and resulted in two newly FDA-approved drugs specific for …
Highly efficient generation of transgenically augmented CAR NK cells overexpressing CXCR4
Natural killer (NK) cells are a noteworthy lymphocyte subset in cancer adoptive cell therapy.
NK cells initiate innate immune responses against infections and malignancies with natural …
NK cells initiate innate immune responses against infections and malignancies with natural …
At the Bench: Pre-clinical evidence for multiple functions of CXCR4 in cancer
Signaling through chemokine receptor, CXC chemokine receptor type 4 (CXCR4) regulates
essential processes in normal physiology, including embryogenesis, tissue repair …
essential processes in normal physiology, including embryogenesis, tissue repair …