The role of cytochrome P450s in insect toxicology and resistance

R Nauen, C Bass, R Feyereisen… - Annual Review of …, 2022 - annualreviews.org
Insect cytochrome P450 monooxygenases (P450s) perform a variety of important
physiological functions, but it is their role in the detoxification of xenobiotics, such as natural …

The impact of transposable elements in adaptive evolution

L Schrader, J Schmitz - Molecular Ecology, 2019 - Wiley Online Library
The growing knowledge about the influence of transposable elements (TE s) on (a) long‐
term genome and transcriptome evolution;(b) genomic, transcriptomic and epigenetic …

Understanding the effects of sublethal pesticide exposure on honey bees: a role for probiotics as mediators of environmental stress

JA Chmiel, BA Daisley, AP Pitek… - Frontiers in Ecology …, 2020 - frontiersin.org
Managed populations of the European honey bee (Apis mellifera) support the production of
a global food supply. This important role in modern agriculture has rendered honey bees …

[HTML][HTML] Does resistance really carry a fitness cost?

C Bass - Current opinion in insect science, 2017 - Elsevier
Highlights•New resistance mutations are predicted to be costly but this is rarely shown in the
field.•Fitness costs are predicted to be offset by 'modifier'loci but specific examples are …

Transposable elements and human diseases: mechanisms and implication in the response to environmental pollutants

B Chénais - International journal of molecular sciences, 2022 - mdpi.com
Transposable elements (TEs) are recognized as major players in genome plasticity and
evolution. The high abundance of TEs in the human genome, especially the Alu and Long …

Regulating resistance: CncC: Maf, antioxidant response elements and the overexpression of detoxification genes in insecticide resistance

CS Wilding - Current opinion in insect science, 2018 - Elsevier
Highlights•CncC (Nrf2 ortholog) is a key activator of transcription in insecticide
resistance.•CncC is frequently upregulated (constitutively) in resistant insects.•CncC binds to …

Comparative analysis of the detoxification gene inventory of four major Spodoptera pest species in response to xenobiotics

D Amezian, R Nauen, G Le Goff - Insect Biochemistry and Molecular …, 2021 - Elsevier
Abstract The genus Spodoptera (Lepidoptera: Noctuidae) comprises some of the most
polyphagous and destructive agricultural pests worldwide. The success of many species of …

Cytpchrome P450 CYP4G68 Is Associated with Imidacloprid and Thiamethoxam Resistance in Field Whitefly, Bemisia tabaci (Hemiptera: Gennadius)

J Liang, J Yang, J Hu, B Fu, P Gong, T Du, H Xue… - Agriculture, 2022 - mdpi.com
The superfamily cytochrome P450s is involved in the evolution of insecticide resistance.
However, whether CYP4G68, a differentially expressed gene identified from our …

Enthralling genetic regulatory mechanisms meddling insecticide resistance development in insects: role of transcriptional and post-transcriptional events

C Muthu Lakshmi Bavithra, M Murugan… - Frontiers in Molecular …, 2023 - frontiersin.org
Insecticide resistance in insects severely threatens both human health and agriculture,
making insecticides less compelling and valuable, leading to frequent pest management …

Cytochrome P450 monooxygenase systems: Diversity and plasticity for adaptive stress response

IM Mokhosoev, DV Astakhov, AA Terentiev… - Progress in Biophysics …, 2024 - Elsevier
Superfamily of cytochromes P450 (CYPs) is composed of heme-thiolate-containing
monooxygenase enzymes, which play crucial roles in the biosynthesis, bioactivation, and …