Anabolic steroids and tendons: A review of their mechanical, structural, and biologic effects
One of the suspected deleterious effects of androgenic‐anabolic steroids (AAS) is the
increased risk for tendon rupture. However, investigations to date have produced …
increased risk for tendon rupture. However, investigations to date have produced …
[HTML][HTML] Translational therapy from preclinical animal models for muscle degeneration after rotator cuff injury
Chronic rotator cuff tears are debilitating diseases which significantly affect patients' quality
of life and pose substantial financial burden to the society. The intraoperative reparability of …
of life and pose substantial financial burden to the society. The intraoperative reparability of …
Sarcolab pilot study into skeletal muscle's adaptation to long-term spaceflight
Spaceflight causes muscle wasting. The Sarcolab pilot study investigated two astronauts
with regards to plantar flexor muscle size, architecture, and function, and to the underlying …
with regards to plantar flexor muscle size, architecture, and function, and to the underlying …
Spatial transcriptomics tools allow for regional exploration of heterogeneous muscle pathology in the pre-clinical rabbit model of rotator cuff tear
S Ruoss, MC Esparza, LS Vasquez-Bolanos… - Journal of orthopaedic …, 2022 - Springer
Background Conditions affecting skeletal muscle, such as chronic rotator cuff tears, low back
pain, dystrophies, and many others, often share changes in muscle phenotype …
pain, dystrophies, and many others, often share changes in muscle phenotype …
The role of mechanobiology in progression of rotator cuff muscle atrophy and degeneration
Rotator cuff (RC) muscles undergo several detrimental changes following mechanical
unloading resulting from RC tendon tear. In this review, we highlight the pathological causes …
unloading resulting from RC tendon tear. In this review, we highlight the pathological causes …
[HTML][HTML] Isometric Fatigue Resistance of Lumbar Extensors and Cardiovascular Strain in Lower Back Pain Patients Are Associated with Angiotensin-Converting …
Background: We tested whether gene polymorphisms for angiotensin-converting enzyme
(ACE, rs1799752) and tenascin-C (TNC, rs2104772) are associated with variability in …
(ACE, rs1799752) and tenascin-C (TNC, rs2104772) are associated with variability in …
Structural Musculotendinous Parameters That Predict Failed Tendon Healing After Rotator Cuff Repair
MGL Olthof, M Flück, P Borbas… - … Journal of Sports …, 2023 - journals.sagepub.com
Background: Healing of the rotator cuff after repair constitutes a major clinical challenge with
reported high failure rates. Identifying structural musculotendinous predictors for failed …
reported high failure rates. Identifying structural musculotendinous predictors for failed …
Interventions used to mitigate muscle fatty degeneration following the repair of massive rotator cuff tears. A systematic review of animal studies
D Stamiris, A Valasidis, A Cheva, K Papavasiliou… - … & Traumatology: Surgery …, 2024 - Elsevier
Background Muscle fatty degeneration following rotator cuff tears has been unequivocally
associated with poorer functional outcomes and increased risk for retear following rotator …
associated with poorer functional outcomes and increased risk for retear following rotator …
Tendon and multiomics: advantages, advances, and opportunities
P Sarmiento, D Little - NPJ Regenerative Medicine, 2021 - nature.com
Tendons heal by fibrosis, which hinders function and increases re-injury risk. Yet the biology
that leads to degeneration and regeneration of tendons is not completely understood …
that leads to degeneration and regeneration of tendons is not completely understood …
[HTML][HTML] Down-regulation of mitochondrial metabolism after tendon release primes lipid accumulation in rotator cuff muscle
Atrophy and fat accumulation are debilitating aspects of muscle diseases and are rarely
prevented. Using a vertical approach combining anatomic techniques with omics …
prevented. Using a vertical approach combining anatomic techniques with omics …