[HTML][HTML] HRP2: transforming malaria diagnosis, but with caveats

KE Poti, DJ Sullivan, AM Dondorp, CJ Woodrow - Trends in parasitology, 2020 - cell.com
The major growth in point-of-care malaria diagnosis over the past decade has been based
on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect …

Malaria rapid diagnostic tests: challenges and prospects

JC Mouatcho, JPD Goldring - Journal of medical …, 2013 - microbiologyresearch.org
In the last decade, there has been an upsurge of interest in developing malaria rapid
diagnostic test (RDT) kits for the detection of Plasmodium species. Three antigens …

Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia

SM Feleke, EN Reichert, H Mohammed… - Nature …, 2021 - nature.com
In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …

A Large Proportion of P. falciparum Isolates in the Amazon Region of Peru Lack pfhrp2 and pfhrp3: Implications for Malaria Rapid Diagnostic Tests

D Gamboa, MF Ho, J Bendezu, K Torres, PL Chiodini… - PloS one, 2010 - journals.plos.org
Background Malaria rapid diagnostic tests (RDTs) offer significant potential to improve the
diagnosis of malaria, and are playing an increasing role in malaria case management …

[HTML][HTML] Major threat to malaria control programs by Plasmodium falciparum lacking histidine-rich protein 2, Eritrea

A Berhane, K Anderson, S Mihreteab… - Emerging infectious …, 2018 - ncbi.nlm.nih.gov
False-negative results for Plasmodium falciparum histidine-rich protein (HRP) 2–based
rapid diagnostic tests (RDTs) are increasing in Eritrea. We investigated HRP gene 2/3 …

Requirements for high impact diagnostics in the developing world

M Urdea, LA Penny, SS Olmsted, MY Giovanni… - Nature, 2006 - nature.com
This paper focuses on the technologies required to meet the global health diagnostics
needs presented in the previous papers, highlighting how new diagnostic technologies …

[HTML][HTML] False-negative rapid diagnostic tests for malaria and deletion of the histidine-rich repeat region of the hrp2 gene

OA Koita, OK Doumbo, A Ouattara, LK Tall… - The American journal …, 2012 - ncbi.nlm.nih.gov
We identified 480 persons with positive thick smears for asexual Plasmodium falciparum
parasites, of whom 454 had positive rapid diagnostic tests (RDTs) for the histidine-rich …

Update on rapid diagnostic testing for malaria

CK Murray, RA Gasser Jr, AJ Magill… - Clinical microbiology …, 2008 - Am Soc Microbiol
To help mitigate the expanding global impact of malaria, with its associated increasing drug
resistance, implementation of prompt and accurate diagnosis is needed. Malaria is …

Ensuring quality and access for malaria diagnosis: how can it be achieved?

D Bell, C Wongsrichanalai, JW Barnwell - Nature Reviews Microbiology, 2006 - nature.com
The replacement of conventional antimalarial drugs with high-cost, artemisinin-based
alternatives has created a gap in the successful management of malaria. This gap reflects …

Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial

H Reyburn, H Mbakilwa, R Mwangi, O Mwerinde… - Bmj, 2007 - bmj.com
Objective To compare rapid diagnostic tests (RDTs) for malaria with routine microscopy in
guiding treatment decisions for febrile patients. Design Randomised trial. Setting Outpatient …