A significant challenge for neuroscientists is to determine how both electrical and chemical
signals affect the activity of cells and circuits and how the nervous system subsequently …

Background Fibrous dysplasia (FD) is a rare genetic bone disorder resulting in an
overproduction of cAMP leading to a structurally unsound tissue, caused by a genetic …

Fibrous dysplasia of bone (FD) is a crippling skeletal disease associated with postzygotic
mutations (R201C, R201H) of the gene encoding the α subunit of the stimulatory G protein …

Endemic fluorosis is caused by the intake of high environmental fluoride, which causes
dental and skeletal fluorosis. Osteoblast proliferation and activation is closely related to …

We recently reported the generation and initial characterization of the first direct model of
human fibrous dysplasia (FD; OMIM# 174800), obtained through the constitutive systemic …

FGF9 has complex and important roles in skeletal development and repair. We have
previously observed that Fgf9 expression in osteoblasts (OBs) is regulated by G protein …

ABSTRACT G‐protein‐coupled receptors (GPCRs) are key regulators of skeletal
homeostasis and are likely important in fracture healing. Because GPCRs can activate …

Introduction The controlled expression of many genes, including G-protein coupled
receptors (GPCRs), is important for delineating gene functions in complex model systems …

Normal hearing requires exquisite cooperation between bony and sensorineural structures
within the cochlea. For example, the inner ear secretes proteins such as osteoprotegrin …

ABSTRACT GαS is a heterotrimeric G protein that transduces signals from activated G
protein‐coupled receptors on the cell surface to stimulate adenylyl cyclase/cyclic adenosine …