Staphylococcus aureus Toxins: An Update on Their Pathogenic Properties and Potential Treatments

N Ahmad-Mansour, P Loubet, C Pouget… - Toxins, 2021 - mdpi.com
Staphylococcus aureus is a clinically important pathogen that causes a wide range of
human infections, from minor skin infections to severe tissue infection and sepsis. S. aureus …

Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

Y Wen, J Lambrecht, C Ju, F Tacke - Cellular & molecular immunology, 2021 - nature.com
Macrophages, which are key cellular components of the liver, have emerged as essential
players in the maintenance of hepatic homeostasis and in injury and repair processes in …

Endothelial dysfunction and immunothrombosis in sepsis

E Maneta, E Aivalioti, S Tual-Chalot… - Frontiers in …, 2023 - frontiersin.org
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …

Staphylococcus aureus bloodstream infections: pathogenesis and regulatory mechanisms

JM Kwiecinski, AR Horswill - Current opinion in microbiology, 2020 - Elsevier
Highlights•Phagocytes play both protective and detrimental roles in containing bloodstream
S. aureus.•S. aureus hijacks the host coagulation system and uses it to bind host …

Recent advances in anti-virulence therapeutic strategies with a focus on dismantling bacterial membrane microdomains, toxin neutralization, quorum-sensing …

O Fleitas Martínez, MH Cardoso, SM Ribeiro… - Frontiers in cellular …, 2019 - frontiersin.org
Antimicrobial resistance constitutes one of the major challenges facing humanity in the
Twenty-First century. The spread of resistant pathogens has been such that the possibility of …

Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies

J Clegg, E Soldaini, RM McLoughlin… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is one of the most important human pathogens worldwide. Its high
antibiotic resistance profile reinforces the need for new interventions like vaccines in …

The era of thromboinflammation: platelets are dynamic sensors and effector cells during infectious diseases

L Guo, MT Rondina - Frontiers in immunology, 2019 - frontiersin.org
Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

Understanding infection-induced thrombosis: lessons learned from animal models

N Beristain-Covarrubias, M Perez-Toledo… - Frontiers in …, 2019 - frontiersin.org
Thrombosis is a common consequence of infection that is associated with poor patient
outcome. Nevertheless, the mechanisms by which infection-associated thrombosis is …

The gut–liver axis in sepsis: interaction mechanisms and therapeutic potential

X Zhang, H Liu, K Hashimoto, S Yuan, J Zhang - Critical care, 2022 - Springer
Sepsis is a potentially fatal condition caused by dysregulation of the body's immune
response to an infection. Sepsis-induced liver injury is considered a strong independent …

Immunothrombosis and thromboinflammation in host defense and disease

K Martinod, C Deppermann - Platelets, 2021 - Taylor & Francis
Platelets are increasingly being recognized for playing roles beyond thrombosis and
hemostasis. Today we know that they mediate inflammation by direct interactions with innate …