[HTML][HTML] Endometriosis-associated infertility: From pathophysiology to tailored treatment

G Bonavina, HS Taylor - Frontiers in endocrinology, 2022 - frontiersin.org
Despite the clinically recognized association between endometriosis and infertility, the
mechanisms implicated in endometriosis-associated infertility are not fully understood …

Histone deacetylases (HDACs): evolution, specificity, role in transcriptional complexes, and pharmacological actionability

G Milazzo, D Mercatelli, G Di Muzio, L Triboli… - Genes, 2020 - mdpi.com
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …

Female reproductive dysfunctions and the gut microbiota

SB Chadchan, V Singh… - Journal of molecular …, 2022 - jme.bioscientifica.com
The gut microbiome is considered an endocrine organ that can influence distant organs and
associated biological pathways. Recent advances suggest that gut microbial homeostasis is …

Epigenetic dysregulation in endometriosis: implications for pathophysiology and therapeutics

RM Marquardt, DN Tran, BA Lessey… - Endocrine …, 2023 - academic.oup.com
Endometriosis is a prevalent gynecological condition associated with pelvic pain and
infertility. Despite more than a century of research, the etiology of endometriosis still eludes …

Research priorities for endometriosis: recommendations from a global consortium of investigators in endometriosis

PAW Rogers, GD Adamson, M Al-Jefout… - Reproductive …, 2017 - journals.sagepub.com
The 3rd International Consensus Workshop on Research Priorities in Endometriosis was
held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis …

Recent insights on the genetics and epigenetics of endometriosis

B Borghese, KT Zondervan, MS Abrao… - Clinical …, 2017 - Wiley Online Library
Endometriosis is a gynecologic disease affecting up to 10% of the women and a major
cause of pain and infertility. It is characterized by the implantation of functional endometrial …

Histone acetylation and the role of histone deacetylases in normal cyclic endometrium

P Gujral, V Mahajan, AC Lissaman… - Reproductive Biology …, 2020 - Springer
Histone acetylation is a critical epigenetic modification that changes chromatin architecture
and regulates gene expression by opening or closing the chromatin structure. It plays an …

Omics-based novel strategies in the diagnosis of endometriosis

M Samare-Najaf, SA Razavinasab… - Critical Reviews in …, 2024 - Taylor & Francis
Endometriosis, an enigmatic and chronic disorder, is considered a debilitating condition
despite being benign. Globally, this gynecologic disorder affects up to 10% of females of …

Loss of HDAC3 results in nonreceptive endometrium and female infertility

TH Kim, JY Yoo, KC Choi, JH Shin, RE Leach… - Science translational …, 2019 - science.org
Endometriosis is a disease in which tissue that normally grows inside the uterus grows
outside the uterus and causes chronic pelvic pain and infertility. However, the exact …

Genetic, epigenetic, and steroidogenic modulation mechanisms in endometriosis

A Zubrzycka, M Zubrzycki, E Perdas… - Journal of clinical …, 2020 - mdpi.com
Endometriosis is a chronic gynecological disease, affecting up to 10% of reproductive-age
women. The exact cause of the disease is unknown; however, it is a heritable condition …