Highlights•mAbs are suitable to replace rabies immunoglobulins in rabies prophylaxis.•mAb
cocktails are recommended to limit the risk of failure due limited coverage and viral …

Monoclonal antibodies (mABs) are safe and effective proteins produced in laboratory that
may be used to target a single epitope of a highly conserved protein of a virus or a bacterial …

Background Lack of access to rabies immunoglobulin (RIG) contributes to high rabies
mortality. A recombinant human monoclonal antibody (SII RMAb) was tested in a …

Currently available rabies post‐exposure prophylaxis (PEP) for use in humans includes
equine or human rabies immunoglobulins (RIG). The replacement of RIG with an equally or …

Rabies virus (RABV) causes lethal encephalitis and is responsible for approximately 60,000
deaths per year. As the sole virion-surface protein, the rabies virus glycoprotein (RABV-G) …

Despite successful control in many parts of the world, rabies virus continues to result in tens
of thousands of deaths each year. Death from rabies can be prevented by timely and …

Rabies is a highly fatal zoonotic disease caused by the rabies virus invading the central
nervous system. When suspected of exposure to the rabies virus, post-exposure prophylaxis …

Novel lyssaviruses, the causative agents of rabies, continue to be described mostly due to
increased surveillance in bat hosts. Biologicals for the prevention of rabies in humans have …

Coyotes (Canis latrans) have a broad geographic distribution across North and Central
America. Despite their widespread presence in urban environments in the USA, there is …

Human rabies is a serious public health problem that can't be ignored. Rabies immune
globulin (RIG) is an indispensable component of rabies post-exposure prophylaxis (PEP) …