The highly conserved Notch signalling pathway functions in many different developmental
and homeostatic processes, which raises the question of how this pathway can achieve …

The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally
active intracellular domain, on force to unfold a protective domain and permit proteolysis, on …

Patterns are ubiquitous in living systems and underlie the dynamic organization of cells,
tissues, and embryos. Mathematical frameworks have been devised to account for the self …

Most cells in our body communicate during development and throughout life via Notch
receptors and their ligands. Notch receptors relay information from the cell surface to the …

Vertebrate pigment patterns are diverse and fascinating adult traits that allow animals to
recognize conspecifics, attract mates, and avoid predators. Pigment patterns in fish are …

Self-organization is pervasive in development, from symmetry breaking in the early embryo
to tissue patterning and morphogenesis. For a few model systems, the underlying molecular …

The melanocortin system is a complex neuroendocrine signaling mechanism involved in
numerous physiological processes in vertebrates, including pigmentation, steroidogenesis …

Thyroid hormone (TH) regulates diverse developmental events and can drive disparate
cellular outcomes. In zebrafish, TH has opposite effects on neural crest derived pigment …

Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides
regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the …

Our understanding of the neural crest, a key vertebrate innovation, is built upon studies of
multiple model organisms. Early research on neural crest cells (NCCs) was dominated by …