Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …

Airway remodeling comprises the structural changes of airway walls, induced by repeated
injury and repair processes. It is characterized by the changes of tissue, cellular, and …

Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

Changes in extracellular matrix (ECM) components in the lungs are associated with the
progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease …

Asthma is a chronic disease of the airways that has long been viewed predominately as an
inflammatory condition. Accordingly, current therapeutic interventions focus primarily on …

Human neutrophils, the most abundant circulating leukocytes, are fundamental components
of the host response against different pathogens. Until a few years ago, neutrophils received …

Rationale: Airway remodeling and inflammation are characteristic features of adult asthma
that are still poorly investigated in childhood asthma. Objectives: To examine epithelial and …

Rationale: Despite long-term therapy with corticosteroids, patients with severe asthma
develop irreversible airway obstruction. Objectives: To evaluate if there are structural and …