Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …

The sensation of pain alerts us to real or impending injury and triggers appropriate
protective responses. Unfortunately, pain often outlives its usefulness as a warning system …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

A cardinal feature of inflammation is heightened pain sensitivity at the site of the inflamed
tissue. This results from the local release by immune and injured cells of nociceptor …

Nociception is essential for survival whereas pathological pain is maladaptive and often
unresponsive to pharmacotherapy. Voltage-gated sodium channels, Nav1. 1–Nav1. 9, are …

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …

Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium
channels. Here we examined the role of the sensory-neuron-specific (SNS) TTX-resistant …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …

Sodium channel Nav1. 9 is expressed in peripheral nociceptive neurons, as well as visceral
afferents, and has been shown to act as a threshold channel. Painful peripheral neuropathy …