Impact of cryopreservation and freeze-thawing on therapeutic properties of mesenchymal stromal/stem cells and other common cellular therapeutics

C Cottle, AP Porter, A Lipat, C Turner-Lyles… - Current stem cell …, 2022 - Springer
Abstract Purpose of Review Cryopreservation and its associated freezing and thawing
procedures–short “freeze-thawing”–are among the final steps in economically viable …

[HTML][HTML] Advances in radiation-induced heart disease diagnosis and treatment

K Wang, C Ye, L Luo, C Yan - Radiation Medicine and Protection, 2024 - Elsevier
Over the past decades, the survival rates of patients with cancer have significantly increased
owing to advancements in cancer treatment strategies. Radiotherapy has become an …

Pollen derived macromolecules serve as a new class of ice-nucleating cryoprotectants

KA Murray, NLH Kinney, CA Griffiths, M Hasan… - Scientific Reports, 2022 - nature.com
Cryopreservation of biological material is vital for existing and emerging biomedical and
biotechnological research and related applications, but there remain significant challenges …

[HTML][HTML] An evaluation of the heat test for the ice-nucleating ability of minerals and biological material

MI Daily, MD Tarn, TF Whale… - Atmospheric …, 2022 - amt.copernicus.org
Ice-nucleating particles (INPs) are atmospheric aerosol particles that can strongly influence
the radiative properties and precipitation onset in mixed-phase clouds by triggering ice …

Chemically induced extracellular ice nucleation reduces intracellular ice formation enabling 2D and 3D cellular cryopreservation

KA Murray, Y Gao, CA Griffiths, NLH Kinney, Q Guo… - Jacs Au, 2023 - ACS Publications
3D cell assemblies such as spheroids reproduce the in vivo state more accurately than
traditional 2D cell monolayers and are emerging as tools to reduce or replace animal …

A highly active mineral-based ice nucleating agent supports in situ cell cryopreservation in a high throughput format

MI Daily, TF Whale, P Kilbride… - Journal of the …, 2023 - royalsocietypublishing.org
Cryopreservation of biological matter in microlitre scale volumes of liquid would be useful for
a range of applications. At present, it is challenging because small volumes of water tend to …

Cryopreservation of assay-ready hepatocyte monolayers by chemically-induced ice nucleation: preservation of hepatic function and hepatotoxicity screening …

RMF Tomás, R Dallman, TR Congdon… - Biomaterials Science, 2023 - pubs.rsc.org
Cell culture plays a critical role in biomedical discovery and drug development. Primary
hepatocytes and hepatocyte-derived cell lines are especially important cellular models for …

[HTML][HTML] Recent Advances in Antifreeze Peptide Preparation: A Review

B Xia, J Wang, H Chen, S Lin, B Pan, N Wang - Molecules, 2024 - mdpi.com
Antifreeze agents play a critical role in various fields including tissue engineering, gene
therapy, therapeutic protein production, and transplantation. Commonly used antifreeze …

Mesenchymal Stem Cells-Conditioned Medium; An Effective Cell-Free Therapeutic Option for in vitro Maturation of Oocytes

FK Pour, MA Gale Dari, M Ramazii… - Current Stem Cell …, 2024 - benthamdirect.com
Infertility is a major reproductive health issue worldwide. One of the main problems in
infertile women is the failure to generate or release a mature egg. Therefore, the …

Optimizing cryopreservation strategies for scalable cell therapies: A comprehensive review with insights from iPSC‐derived therapies

M Dobruskin, G Toner, R Kander - Biotechnology Progress, 2024 - Wiley Online Library
Off‐the‐shelf cell therapies hold significant curative potential for conditions, such as
Parkinson's disease and heart failure. However, these therapies face unique …